Evidence map›Paper›PMID 39642392›Full record

ReviewBiofabrication2024

Modeling intratumor heterogeneity in breast cancer.

Elizabeth McDonough, Margarida Barroso, Fiona Ginty, David T Corr

Abstract readReview
In one paragraph

Review in Biofabrication, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Elizabeth McDonoughDepartment of Biomedical Engineering, Rensselaer Polytechnic Institute, 110 Eighth Street, Troy, NY 12180, United States of America.ORCID 0000-0001-7524-8260
Margarida BarrosoDepartment of Molecular and Cellular Physiology, Albany Medical College, Albany, NY 12208, United States of America.ORCID 0000-0002-0407-3181
Fiona GintyGE HealthCare Technology & Innovation Center, 1 Research Circle, Niskayuna, NY 12309, United States of America.
David T CorrDepartment of Biomedical Engineering, Rensselaer Polytechnic Institute, 110 Eighth Street, Troy, NY 12180, United States of America.ORCID 0000-0002-4059-8591

Funding

In vivo Macroscopic Fluorescence Lifetime Molecular Optical ImagingR01CA250636 · NCI · RENSSELAER POLYTECHNIC INSTITUTE · PI BARROSO, MARGARIDA, INTES, XAVIER · 2020 to 2023
$2.9M
Endosome-mitochondria interactions in breast cancer cellsR01CA233188 · NCI · ALBANY MEDICAL COLLEGE · PI BARROSO, MARGARIDA · 2020 to 2024
$2.8M
NCI NIH HHS R01 CA233188NCI NIH HHS R01 CA250636
6 · The paper itself

Abstract

Reduced therapy response in breast cancer has been correlated with heterogeneity in biomarker composition, expression level, and spatial distribution of cancer cells within a patient tumor. Thus, there is a need for models to replicate cell-cell, cell-stromal, and cell-microenvironment interactions during cancer progression. Traditional two-dimensional (2D) cell culture models are convenient but cannot adequately represent tumor microenvironment histological organization,

Indexed as

BioprintingBreast NeoplasmsTumor MicroenvironmentAnimalsFemaleHumansModels, BiologicalPrinting, Three-Dimensional3D modelsbioprintingbreast cancerdrug responseheterogeneity

Identifiers

PMID39642392
PMCPMC11740194

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.