Evidence map›Paper›PMID 39642382›Full record

ReviewAmerican journal of respiratory cell and molecular biology2025

From Epithelium to Therapy: Transitional Cells in Lung Fibrosis.

Sarah Y Shin, Jichao Chen, Irit Milman Krentsis, Yair Reisner, Rodeo Abrencillo, Rahat Hussain, Danielle Wu, Harry Karmouty-Quintana

Abstract readReview
In one paragraph

Review in American journal of respiratory cell and molecular biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. A precision approach to translational research in acute lung injury.American journal of respiratory and critical care medicine · 2026
    Article
  5. Review
  6. Engineering function in lung biology: integrating imaging, regenerative constructs, and functional biodesign.American journal of physiology. Lung cellular and molecular physiology · 2026
    Review
  7. Article
  8. Review
  9. Article
  10. SCPEP1Frontiers in immunology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Sarah Y ShinDepartment of Biochemistry and Molecular Biology and.ORCID 0000-0003-2367-7623
Jichao ChenDepartment of Pediatrics, Cincinnati Children's Hospital, Cincinnati, Ohio.
Irit Milman KrentsisDepartment of Stem Cell Transplantation and Cell Therapy, MD Anderson Cancer Center, Houston, Texas.
Yair ReisnerDepartment of Stem Cell Transplantation and Cell Therapy, MD Anderson Cancer Center, Houston, Texas.
Rodeo AbrencilloDivision of Pulmonary, Critical Care, and Sleep Medicine, Department of Internal Medicine, McGovern Medical School, Houston, Texas.
Rahat HussainCenter for Advanced Cardiopulmonary Therapies and Transplantation, University of Texas Health Science Center at Houston, Houston, Texas.
Danielle WuDepartment of Diagnostic and Biomedical Sciences, School of Dentistry, UTHealth Houston, Houston, Texas.
Harry Karmouty-QuintanaDepartment of Biochemistry and Molecular Biology and.ORCID 0000-0003-4753-9823

Funding

Transcriptional and epigenetic mechanisms of alveologenesis and re-alveologenesisR35HL171346 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI Jichao Chen · 2024 to 2026
$3.3M
Sineoculis Homeobox Homolog 1 (Six1) in Pulmonary FibrosisR01HL157100 · NHLBI · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI KARMOUTY-QUINTANA, HARRY · 2021 to 2025
$2.8M
A mechanistic 3D AI-powered map of genetic chILDU01HL175383 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI Jichao Chen, Kathryn Ann Wikenheiser-Brokamp · 2024 to 2026
$2.4M
3'UTR Shortening In Pulmonary Vascular DiseaseR01HL138510 · NHLBI · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI KARMOUTY-QUINTANA, HARRY · 2017 to 2021
$2.3M
NHLBI NIH HHS 1R01HL138510NHLBI NIH HHS R01 HL138510NHLBI NIH HHS R01 HL157100NHLBI NIH HHS R35 HL171346NHLBI NIH HHS U01 HL175383
6 · The paper itself

Abstract

Patients with idiopathic pulmonary fibrosis and lung fibrosis secondary to infections such as influenza A and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have limited treatment options outside of supportive therapy and lung transplantation. Multiple lung stem cell populations have been implicated in the pathogenesis of lung fibrosis, and more progenitor cell populations continue to be discovered and characterized. In this review, we summarize the functions and differentiation pathways of various cells that constitute the lung epithelium. We then focus on two subpopulations of KRT5

Indexed as

Idiopathic Pulmonary FibrosisPulmonary FibrosisAlveolar Epithelial CellsAnimalsCell DifferentiationCOVID-19EpitheliumHumansLungSARS-CoV-2Stem Cellscell therapyepithelial cellorganoidpulmonary fibrosisstem cell

Identifiers

PMID39642382
PMCPMC12051923

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.