Observational studyAmerican journal of respiratory and critical care medicine2025
Temporal Transitions of the Hyperinflammatory and Hypoinflammatory Phenotypes in Critical Illness.
Abstract readObservational Study
In one paragraph
Observational study in American journal of respiratory and critical care medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed
–field-weighted citation impact
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
37 citing papers in PubMed.
- Subphenotype-specific serum proteomic signatures in patients with ARDS.Journal of intensive care · 2026Article
- Tissue-Resident Macrophage in Inflammation and Cancer.MedComm · 2026Review
- Inflammatory Subphenotypes for Fluid Management in Acute Respiratory Distress Syndrome: A Subgroup-Level Signal, not an Individual Prescription.Critical care explorations · 2026Article
- Beyond binary: rethinking subphenotyping in ARDS as a continuous spectrum.Intensive care medicine · 2026Article
- The Acute Respiratory Distress Syndrome (ARDS): epidemiology, etiology, molecular mechanisms, diagnosis and therapeutic strategies.Molecular biomedicine · 2026Review
- Interleukin-6 is a mediator of therapeutic efficacy in acute lung injury.American journal of respiratory and critical care medicine · 2026Article
- Multiple organ dysfunction syndrome: molecular mechanisms and therapeutic strategies.Signal transduction and targeted therapy · 2026Review
- The molecular ICU: a primer on omics, informatics and the future of precision critical care.Critical care (London, England) · 2026Review
- C-reactive protein-triglyceride glucose index and its dynamic trajectories on all-cause mortality in critically ill children: a longitudinal, retrospective cohort study.Pediatric research · 2026Article
- Early career member highlights from the ERS Respiratory Failure and Mechanical Ventilation Conference 2026.Breathe (Sheffield, England) · 2026Article
- Host-directed immune therapies: a second front in the battle against sepsis.The Journal of clinical investigation · 2026Review
- Measuring and managing pulmonary edema in ARDS: a narrative review.Critical care (London, England) · 2026Review
- Risk heterogeneity within hypoinflammatory acute respiratory failure: continuous probabilities identify high-risk patients masked by binary classification.Intensive care medicine · 2026Article
- Challenges in early detection and prognostication of sepsis: new approaches from the emergency department and intensive care unit.EClinicalMedicine · 2026Review
- Time-varying associations between corticosteroid dose and hospital mortality in ARDS: a sliding-window analysis of MIMIC-IV.BMC pulmonary medicine · 2026Observational
- The bug, the burden, and the biology: beyond host-centric phenotyping in sepsis.The Journal of clinical investigation · 2026Article
- Tocilizumab Efficacy Across Inflammatory Subphenotypes in COVID-19-Related Acute Respiratory Distress Syndrome.Critical care explorations · 2026Article
- Biomarker-guided use of corticosteroids in pneumonia.Pneumonia (Nathan Qld.) · 2026Review
- The "cytokine storm" in infection and sepsis: win the battle but lose the war.Military Medical Research · 2026Review
- Data-driven spatial-temporal framework for exploring the heterogeneity and temporality of sepsis.Chinese medical journal · 2026Review
Corrections and comments
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Authors and funding
12 authors.
Rombout B E van AmstelDepartment of Intensive Care Medicine and.ORCID 0000-0001-9296-8518
Brian BartekDepartment of Anesthesiology, School of Medicine, Washington University, St. Louis, Missouri.
Alexander P J VlaarDepartment of Intensive Care Medicine and.ORCID 0000-0002-3453-7186
Elizabeth GayDepartment of Anesthesiology, School of Medicine, Washington University, St. Louis, Missouri.
Lonneke A van VughtDepartment of Intensive Care Medicine and.
Olaf L CremerDepartment of Intensive Care, University Medical Center Utrecht, Utrecht, the Netherlands.
Tom Van der PollCenter for Experimental and Molecular Medicine, Amsterdam Infection and Immunity, Amsterdam University Medical Center, location University of Amsterdam, Amsterdam, the Netherlands.
Nathan I ShapiroDepartment of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts; and.
Michael A MatthayDivision of Pulmonary, Critical Care, Allergy and Sleep Medicine, University of California, San Francisco, San Francisco, California.
Carolyn S CalfeeDivision of Pulmonary, Critical Care, Allergy and Sleep Medicine, University of California, San Francisco, San Francisco, California.
Pratik SinhaDepartment of Anesthesiology, School of Medicine, Washington University, St. Louis, Missouri.
Lieuwe D J BosDepartment of Intensive Care Medicine and.
Funding
Precision Medicine in the Acute Respiratory Distress SyndromeR35HL140026 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CALFEE, CAROLYN · 2018 to 2024
$6.8MPrecision Medicine in Sepsis with Critical IllnessR35GM142992 · NIGMS · WASHINGTON UNIVERSITY · PI Pratik Sinha · 2021 to 2026
$2.4MClinical Implementation of Molecular Phenotypes of Critical IllnessR01HL173531 · NHLBI · WASHINGTON UNIVERSITY · PI Pratik Sinha · 2025 to 2026
$1.4MNHLBI NIH HHS R01 HL173531NHLBI NIH HHS R35 HL140026NIGMS NIH HHS R35 GM142992NIH HHS GM142992NIH HHS HL140026
Abstract
PubMed holds no abstract for this paper.
Indexed as
Critical IllnessInflammationRespiratory Distress SyndromeSepsisAgedBiomarkersFemaleHumansMaleMiddle AgedPhenotypePrognosisProspective StudiesTime FactorsBiomarkersacute respiratory distress syndromeintensive carephenotypeprecision medicinesepsis
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.