ArticleNeurology2025
Neuroimaging Correlates of 3 Distinct Physical-Cognitive Phenotypes in Cognitively Normal Older Adults: The Gothenburg H70 Cohort Study.
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- Mind, Mood, and Mobility: Rethinking Functional Disability Prevention in Older Adults on the Basis of a Longitudinal Cohort From CHARLS.Journal of the American Heart Association · 2026Article
- Activity profiles and their associations with transitions between fall and dementia: findings from a multistate time-to-event analysis.Alzheimer's research & therapy · 2026Article
- Hand dexterity and mobility independently predict cognition in older adults: a multi-domain regression analysis.Frontiers in aging neuroscience · 2025Article
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Authors and funding
13 authors.
Rui WangFrom the Department of Physical Activity and Health (R.W.), the Swedish School of Sport and Health Sciences, GIH, Stockholm; Division of Clinical Geriatrics (R.W., A.M., O.L., S.S., M.S., M.K., E.W.), Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Karolinska Institute, Solna, Sweden; Wisconsin Alzheimer's Disease Research Center (R.W.), University of Wisconsin School of Medicine and Public Health, Madison; Centre for Ageing and Health (AgeCap) (J.S., O.L., T.R.S., S.K., A.Z., I.S.), Neuropsychiatric Epidemiology Unit, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg, Mölndal; Department of Psychology (J.S.), University of Gothenburg, Göteborg; Neuro Division (J.B.P.), Department of Clinical Neurosciences, Karolinska Institute, Stockholm; FINGERS Brain Health Institute (M.K.), Stockholm; Medical Unit Aging (M.K.), Karolinska University Hospital, Solna, Sweden; Ageing Epidemiology (AGE) Research Unit (M.K.), School of Public Health, Imperial College London, Medical School Building, St Mary's Hospital, United Kingdom; Institute of Public Health and Clinical Nutrition and Institute of Clinical Medicine (M.K.), Neurology, University of Eastern Finland, Kuopio; Aging Research Center (T.R.S.), Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University; and Department of Psychiatry Cognition and Old Age Psychiatry (I.S.), Sahlgrenska University Hospital, Region Västra Götaland, Mölndal, Sweden.ORCID 0000-0001-7209-741X
Anna MarsegliaFrom the Department of Physical Activity and Health (R.W.), the Swedish School of Sport and Health Sciences, GIH, Stockholm; Division of Clinical Geriatrics (R.W., A.M., O.L., S.S., M.S., M.K., E.W.), Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Karolinska Institute, Solna, Sweden; Wisconsin Alzheimer's Disease Research Center (R.W.), University of Wisconsin School of Medicine and Public Health, Madison; Centre for Ageing and Health (AgeCap) (J.S., O.L., T.R.S., S.K., A.Z., I.S.), Neuropsychiatric Epidemiology Unit, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg, Mölndal; Department of Psychology (J.S.), University of Gothenburg, Göteborg; Neuro Division (J.B.P.), Department of Clinical Neurosciences, Karolinska Institute, Stockholm; FINGERS Brain Health Institute (M.K.), Stockholm; Medical Unit Aging (M.K.), Karolinska University Hospital, Solna, Sweden; Ageing Epidemiology (AGE) Research Unit (M.K.), School of Public Health, Imperial College London, Medical School Building, St Mary's Hospital, United Kingdom; Institute of Public Health and Clinical Nutrition and Institute of Clinical Medicine (M.K.), Neurology, University of Eastern Finland, Kuopio; Aging Research Center (T.R.S.), Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University; and Department of Psychiatry Cognition and Old Age Psychiatry (I.S.), Sahlgrenska University Hospital, Region Västra Götaland, Mölndal, Sweden.ORCID 0000-0002-9672-6978
Johan SkoogFrom the Department of Physical Activity and Health (R.W.), the Swedish School of Sport and Health Sciences, GIH, Stockholm; Division of Clinical Geriatrics (R.W., A.M., O.L., S.S., M.S., M.K., E.W.), Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Karolinska Institute, Solna, Sweden; Wisconsin Alzheimer's Disease Research Center (R.W.), University of Wisconsin School of Medicine and Public Health, Madison; Centre for Ageing and Health (AgeCap) (J.S., O.L., T.R.S., S.K., A.Z., I.S.), Neuropsychiatric Epidemiology Unit, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg, Mölndal; Department of Psychology (J.S.), University of Gothenburg, Göteborg; Neuro Division (J.B.P.), Department of Clinical Neurosciences, Karolinska Institute, Stockholm; FINGERS Brain Health Institute (M.K.), Stockholm; Medical Unit Aging (M.K.), Karolinska University Hospital, Solna, Sweden; Ageing Epidemiology (AGE) Research Unit (M.K.), School of Public Health, Imperial College London, Medical School Building, St Mary's Hospital, United Kingdom; Institute of Public Health and Clinical Nutrition and Institute of Clinical Medicine (M.K.), Neurology, University of Eastern Finland, Kuopio; Aging Research Center (T.R.S.), Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University; and Department of Psychiatry Cognition and Old Age Psychiatry (I.S.), Sahlgrenska University Hospital, Region Västra Götaland, Mölndal, Sweden.ORCID 0000-0001-9549-5875
Olof LindbergFrom the Department of Physical Activity and Health (R.W.), the Swedish School of Sport and Health Sciences, GIH, Stockholm; Division of Clinical Geriatrics (R.W., A.M., O.L., S.S., M.S., M.K., E.W.), Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Karolinska Institute, Solna, Sweden; Wisconsin Alzheimer's Disease Research Center (R.W.), University of Wisconsin School of Medicine and Public Health, Madison; Centre for Ageing and Health (AgeCap) (J.S., O.L., T.R.S., S.K., A.Z., I.S.), Neuropsychiatric Epidemiology Unit, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg, Mölndal; Department of Psychology (J.S.), University of Gothenburg, Göteborg; Neuro Division (J.B.P.), Department of Clinical Neurosciences, Karolinska Institute, Stockholm; FINGERS Brain Health Institute (M.K.), Stockholm; Medical Unit Aging (M.K.), Karolinska University Hospital, Solna, Sweden; Ageing Epidemiology (AGE) Research Unit (M.K.), School of Public Health, Imperial College London, Medical School Building, St Mary's Hospital, United Kingdom; Institute of Public Health and Clinical Nutrition and Institute of Clinical Medicine (M.K.), Neurology, University of Eastern Finland, Kuopio; Aging Research Center (T.R.S.), Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University; and Department of Psychiatry Cognition and Old Age Psychiatry (I.S.), Sahlgrenska University Hospital, Region Västra Götaland, Mölndal, Sweden.ORCID 0000-0001-6352-108X
Joana B PereiraFrom the Department of Physical Activity and Health (R.W.), the Swedish School of Sport and Health Sciences, GIH, Stockholm; Division of Clinical Geriatrics (R.W., A.M., O.L., S.S., M.S., M.K., E.W.), Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Karolinska Institute, Solna, Sweden; Wisconsin Alzheimer's Disease Research Center (R.W.), University of Wisconsin School of Medicine and Public Health, Madison; Centre for Ageing and Health (AgeCap) (J.S., O.L., T.R.S., S.K., A.Z., I.S.), Neuropsychiatric Epidemiology Unit, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg, Mölndal; Department of Psychology (J.S.), University of Gothenburg, Göteborg; Neuro Division (J.B.P.), Department of Clinical Neurosciences, Karolinska Institute, Stockholm; FINGERS Brain Health Institute (M.K.), Stockholm; Medical Unit Aging (M.K.), Karolinska University Hospital, Solna, Sweden; Ageing Epidemiology (AGE) Research Unit (M.K.), School of Public Health, Imperial College London, Medical School Building, St Mary's Hospital, United Kingdom; Institute of Public Health and Clinical Nutrition and Institute of Clinical Medicine (M.K.), Neurology, University of Eastern Finland, Kuopio; Aging Research Center (T.R.S.), Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University; and Department of Psychiatry Cognition and Old Age Psychiatry (I.S.), Sahlgrenska University Hospital, Region Västra Götaland, Mölndal, Sweden.ORCID 0000-0002-4604-2711
Sara ShamsFrom the Department of Physical Activity and Health (R.W.), the Swedish School of Sport and Health Sciences, GIH, Stockholm; Division of Clinical Geriatrics (R.W., A.M., O.L., S.S., M.S., M.K., E.W.), Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Karolinska Institute, Solna, Sweden; Wisconsin Alzheimer's Disease Research Center (R.W.), University of Wisconsin School of Medicine and Public Health, Madison; Centre for Ageing and Health (AgeCap) (J.S., O.L., T.R.S., S.K., A.Z., I.S.), Neuropsychiatric Epidemiology Unit, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg, Mölndal; Department of Psychology (J.S.), University of Gothenburg, Göteborg; Neuro Division (J.B.P.), Department of Clinical Neurosciences, Karolinska Institute, Stockholm; FINGERS Brain Health Institute (M.K.), Stockholm; Medical Unit Aging (M.K.), Karolinska University Hospital, Solna, Sweden; Ageing Epidemiology (AGE) Research Unit (M.K.), School of Public Health, Imperial College London, Medical School Building, St Mary's Hospital, United Kingdom; Institute of Public Health and Clinical Nutrition and Institute of Clinical Medicine (M.K.), Neurology, University of Eastern Finland, Kuopio; Aging Research Center (T.R.S.), Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University; and Department of Psychiatry Cognition and Old Age Psychiatry (I.S.), Sahlgrenska University Hospital, Region Västra Götaland, Mölndal, Sweden.ORCID 0000-0002-5133-0224
Mana ShamsFrom the Department of Physical Activity and Health (R.W.), the Swedish School of Sport and Health Sciences, GIH, Stockholm; Division of Clinical Geriatrics (R.W., A.M., O.L., S.S., M.S., M.K., E.W.), Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Karolinska Institute, Solna, Sweden; Wisconsin Alzheimer's Disease Research Center (R.W.), University of Wisconsin School of Medicine and Public Health, Madison; Centre for Ageing and Health (AgeCap) (J.S., O.L., T.R.S., S.K., A.Z., I.S.), Neuropsychiatric Epidemiology Unit, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg, Mölndal; Department of Psychology (J.S.), University of Gothenburg, Göteborg; Neuro Division (J.B.P.), Department of Clinical Neurosciences, Karolinska Institute, Stockholm; FINGERS Brain Health Institute (M.K.), Stockholm; Medical Unit Aging (M.K.), Karolinska University Hospital, Solna, Sweden; Ageing Epidemiology (AGE) Research Unit (M.K.), School of Public Health, Imperial College London, Medical School Building, St Mary's Hospital, United Kingdom; Institute of Public Health and Clinical Nutrition and Institute of Clinical Medicine (M.K.), Neurology, University of Eastern Finland, Kuopio; Aging Research Center (T.R.S.), Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University; and Department of Psychiatry Cognition and Old Age Psychiatry (I.S.), Sahlgrenska University Hospital, Region Västra Götaland, Mölndal, Sweden.ORCID 0009-0003-9066-6470
Miia KivipeltoFrom the Department of Physical Activity and Health (R.W.), the Swedish School of Sport and Health Sciences, GIH, Stockholm; Division of Clinical Geriatrics (R.W., A.M., O.L., S.S., M.S., M.K., E.W.), Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Karolinska Institute, Solna, Sweden; Wisconsin Alzheimer's Disease Research Center (R.W.), University of Wisconsin School of Medicine and Public Health, Madison; Centre for Ageing and Health (AgeCap) (J.S., O.L., T.R.S., S.K., A.Z., I.S.), Neuropsychiatric Epidemiology Unit, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg, Mölndal; Department of Psychology (J.S.), University of Gothenburg, Göteborg; Neuro Division (J.B.P.), Department of Clinical Neurosciences, Karolinska Institute, Stockholm; FINGERS Brain Health Institute (M.K.), Stockholm; Medical Unit Aging (M.K.), Karolinska University Hospital, Solna, Sweden; Ageing Epidemiology (AGE) Research Unit (M.K.), School of Public Health, Imperial College London, Medical School Building, St Mary's Hospital, United Kingdom; Institute of Public Health and Clinical Nutrition and Institute of Clinical Medicine (M.K.), Neurology, University of Eastern Finland, Kuopio; Aging Research Center (T.R.S.), Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University; and Department of Psychiatry Cognition and Old Age Psychiatry (I.S.), Sahlgrenska University Hospital, Region Västra Götaland, Mölndal, Sweden.ORCID 0000-0003-0992-3875
Therese Rydberg SternerFrom the Department of Physical Activity and Health (R.W.), the Swedish School of Sport and Health Sciences, GIH, Stockholm; Division of Clinical Geriatrics (R.W., A.M., O.L., S.S., M.S., M.K., E.W.), Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Karolinska Institute, Solna, Sweden; Wisconsin Alzheimer's Disease Research Center (R.W.), University of Wisconsin School of Medicine and Public Health, Madison; Centre for Ageing and Health (AgeCap) (J.S., O.L., T.R.S., S.K., A.Z., I.S.), Neuropsychiatric Epidemiology Unit, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg, Mölndal; Department of Psychology (J.S.), University of Gothenburg, Göteborg; Neuro Division (J.B.P.), Department of Clinical Neurosciences, Karolinska Institute, Stockholm; FINGERS Brain Health Institute (M.K.), Stockholm; Medical Unit Aging (M.K.), Karolinska University Hospital, Solna, Sweden; Ageing Epidemiology (AGE) Research Unit (M.K.), School of Public Health, Imperial College London, Medical School Building, St Mary's Hospital, United Kingdom; Institute of Public Health and Clinical Nutrition and Institute of Clinical Medicine (M.K.), Neurology, University of Eastern Finland, Kuopio; Aging Research Center (T.R.S.), Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University; and Department of Psychiatry Cognition and Old Age Psychiatry (I.S.), Sahlgrenska University Hospital, Region Västra Götaland, Mölndal, Sweden.ORCID 0000-0001-8202-8522
Silke KernFrom the Department of Physical Activity and Health (R.W.), the Swedish School of Sport and Health Sciences, GIH, Stockholm; Division of Clinical Geriatrics (R.W., A.M., O.L., S.S., M.S., M.K., E.W.), Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Karolinska Institute, Solna, Sweden; Wisconsin Alzheimer's Disease Research Center (R.W.), University of Wisconsin School of Medicine and Public Health, Madison; Centre for Ageing and Health (AgeCap) (J.S., O.L., T.R.S., S.K., A.Z., I.S.), Neuropsychiatric Epidemiology Unit, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg, Mölndal; Department of Psychology (J.S.), University of Gothenburg, Göteborg; Neuro Division (J.B.P.), Department of Clinical Neurosciences, Karolinska Institute, Stockholm; FINGERS Brain Health Institute (M.K.), Stockholm; Medical Unit Aging (M.K.), Karolinska University Hospital, Solna, Sweden; Ageing Epidemiology (AGE) Research Unit (M.K.), School of Public Health, Imperial College London, Medical School Building, St Mary's Hospital, United Kingdom; Institute of Public Health and Clinical Nutrition and Institute of Clinical Medicine (M.K.), Neurology, University of Eastern Finland, Kuopio; Aging Research Center (T.R.S.), Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University; and Department of Psychiatry Cognition and Old Age Psychiatry (I.S.), Sahlgrenska University Hospital, Region Västra Götaland, Mölndal, Sweden.ORCID 0000-0001-7617-7214
Anna ZettergrenFrom the Department of Physical Activity and Health (R.W.), the Swedish School of Sport and Health Sciences, GIH, Stockholm; Division of Clinical Geriatrics (R.W., A.M., O.L., S.S., M.S., M.K., E.W.), Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Karolinska Institute, Solna, Sweden; Wisconsin Alzheimer's Disease Research Center (R.W.), University of Wisconsin School of Medicine and Public Health, Madison; Centre for Ageing and Health (AgeCap) (J.S., O.L., T.R.S., S.K., A.Z., I.S.), Neuropsychiatric Epidemiology Unit, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg, Mölndal; Department of Psychology (J.S.), University of Gothenburg, Göteborg; Neuro Division (J.B.P.), Department of Clinical Neurosciences, Karolinska Institute, Stockholm; FINGERS Brain Health Institute (M.K.), Stockholm; Medical Unit Aging (M.K.), Karolinska University Hospital, Solna, Sweden; Ageing Epidemiology (AGE) Research Unit (M.K.), School of Public Health, Imperial College London, Medical School Building, St Mary's Hospital, United Kingdom; Institute of Public Health and Clinical Nutrition and Institute of Clinical Medicine (M.K.), Neurology, University of Eastern Finland, Kuopio; Aging Research Center (T.R.S.), Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University; and Department of Psychiatry Cognition and Old Age Psychiatry (I.S.), Sahlgrenska University Hospital, Region Västra Götaland, Mölndal, Sweden.ORCID 0000-0002-7182-8417
Ingmar SkoogFrom the Department of Physical Activity and Health (R.W.), the Swedish School of Sport and Health Sciences, GIH, Stockholm; Division of Clinical Geriatrics (R.W., A.M., O.L., S.S., M.S., M.K., E.W.), Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Karolinska Institute, Solna, Sweden; Wisconsin Alzheimer's Disease Research Center (R.W.), University of Wisconsin School of Medicine and Public Health, Madison; Centre for Ageing and Health (AgeCap) (J.S., O.L., T.R.S., S.K., A.Z., I.S.), Neuropsychiatric Epidemiology Unit, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg, Mölndal; Department of Psychology (J.S.), University of Gothenburg, Göteborg; Neuro Division (J.B.P.), Department of Clinical Neurosciences, Karolinska Institute, Stockholm; FINGERS Brain Health Institute (M.K.), Stockholm; Medical Unit Aging (M.K.), Karolinska University Hospital, Solna, Sweden; Ageing Epidemiology (AGE) Research Unit (M.K.), School of Public Health, Imperial College London, Medical School Building, St Mary's Hospital, United Kingdom; Institute of Public Health and Clinical Nutrition and Institute of Clinical Medicine (M.K.), Neurology, University of Eastern Finland, Kuopio; Aging Research Center (T.R.S.), Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University; and Department of Psychiatry Cognition and Old Age Psychiatry (I.S.), Sahlgrenska University Hospital, Region Västra Götaland, Mölndal, Sweden.ORCID 0000-0002-9803-3438
Eric WestmanFrom the Department of Physical Activity and Health (R.W.), the Swedish School of Sport and Health Sciences, GIH, Stockholm; Division of Clinical Geriatrics (R.W., A.M., O.L., S.S., M.S., M.K., E.W.), Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Karolinska Institute, Solna, Sweden; Wisconsin Alzheimer's Disease Research Center (R.W.), University of Wisconsin School of Medicine and Public Health, Madison; Centre for Ageing and Health (AgeCap) (J.S., O.L., T.R.S., S.K., A.Z., I.S.), Neuropsychiatric Epidemiology Unit, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg, Mölndal; Department of Psychology (J.S.), University of Gothenburg, Göteborg; Neuro Division (J.B.P.), Department of Clinical Neurosciences, Karolinska Institute, Stockholm; FINGERS Brain Health Institute (M.K.), Stockholm; Medical Unit Aging (M.K.), Karolinska University Hospital, Solna, Sweden; Ageing Epidemiology (AGE) Research Unit (M.K.), School of Public Health, Imperial College London, Medical School Building, St Mary's Hospital, United Kingdom; Institute of Public Health and Clinical Nutrition and Institute of Clinical Medicine (M.K.), Neurology, University of Eastern Finland, Kuopio; Aging Research Center (T.R.S.), Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University; and Department of Psychiatry Cognition and Old Age Psychiatry (I.S.), Sahlgrenska University Hospital, Region Västra Götaland, Mölndal, Sweden.ORCID 0000-0002-3115-2977
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
objectivesIndividuals aged 70 and older frequently experience an increased risk of deficits in both physical and cognitive functions. However, the natural progression and interrelationship of these deficits, as well as their neurologic correlates, remain unclear. We aimed to classify the data-driven physical-cognitive phenotypes and then investigate their associations with neuroimaging markers.
methodsThis cross-sectional study included 70-year-old participants from the Gothenburg H70 Birth Cohort (2014-2016). Based on physical performance (grip strength, balance, walking speed, and chair stand) and cognitive measures (episodic memory, perceptual speed, executive function, verbal fluency, and visuospatial abilities), we applied latent class analysis to identify physical-cognitive phenotypes. Based on the brain MRI measurements, 3 groups of neuroimaging markers were involved-neurodegeneration, cerebral small vessel disease (cSVD), and microstructural white matter (WM) integrity. We performed multinomial logistic regressions to examine the differences between the physical-cognitive phenotypes.
resultsIn total, 1,140 participants (female: 53.3%) without dementia and disability were included in the study, with 721 (female: 52.2%) undergoing MRI scans. Three physical-cognitive phenotypes were identified: an "optimal" group characterized by high performance in both physical and cognitive functions, an "intermediate" group showing a slight reduction in both domains, and a "physical deficit" group marked by a significant reduction in physical performance. Compared with the optimal group, the other 2 groups were more likely to present with vascular risk factors. The physical deficit group had higher odds of experiencing depression compared with the intermediate group (adjusted odds ratio [aOR] 2.9, 95% CI 1.4-5.9). Compared with the optimal group, the odds of presenting all 3 severe neuroimaging markers were higher in both the intermediate (aOR 3.4, 95% CI 1.5-7.9) and physical deficit (aOR 10.3, 95% CI 2.4-45.0) groups. DISCUSSION: This study highlights the variability in physical and cognitive performance among older adults and suggests that neuroimaging markers of neurodegeneration, cSVD, and microstructural WM integrity may account for these variations. Our findings indicate the potential for developing group-based strategies to prevent and manage age-related functional decline. Further research with larger sample sizes is needed to deepen our understanding of physical-cognitive decline patterns.
Indexed as
Cerebral Small Vessel DiseasesCognitionMagnetic Resonance ImagingNeuroimagingPhenotypeWhite MatterAgedBrainCohort StudiesCross-Sectional StudiesFemaleHand StrengthHumansMaleNeuropsychological TestsPostural Balance
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