Evidence map›Paper›PMID 39642329›Full record

Trial reportJCO clinical cancer informatics2024

Symptom Monitoring App Use Associated With Medication Adherence Among Woman Survivors of Breast Cancer on Adjuvant Endocrine Therapy.

Rebecca A Krukowski, Xin Hu, Sara Arshad, Janeane N Anderson, Edward Stepanski, Gregory A Vidal, Lee S Schwartzberg, Ilana Graetz

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in JCO clinical cancer informatics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Rebecca A KrukowskiDepartment of Public Health Sciences, University of Virginia Comprehensive Cancer Center and School of Medicine, Charlottesville, VA.ORCID 0000-0001-9193-2783
Xin HuDepartment of Public Health Sciences, University of Virginia Comprehensive Cancer Center and School of Medicine, Charlottesville, VA.ORCID 0000-0003-1097-3300
Sara ArshadDepartment of Health Policy and Management, Emory University, Atlanta, GA.
Janeane N AndersonDepartment of Community and Population Health, University of Tennessee Health Science Center, Memphis, TN.ORCID 0000-0003-2602-6957
Edward StepanskiOvation.io, Cambridge, MA.
Gregory A VidalWest Cancer Center and the Lee S. Schwartzberg Research Institute, Germantown, TN.ORCID 0000-0003-3325-6224
Lee S SchwartzbergRenown Institute for Cancer and University of Nevada, Reno, NV.ORCID 0000-0002-7433-3428
Ilana GraetzDepartment of Radiation Oncology, Emory University, Atlanta, GA.ORCID 0000-0003-3664-5815

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI SELWYN M VICKERS · 1985 to 2026
$347.4M
XRAY CRYSTALLOGRAPHYP30CA013148 · NCI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Omer Jamy · 1985 to 2026
$165.9M
PILOT STUDY--SUBSTRATE METABOLISM IN EXTREMELY LOW BIRTH WEIGHT INFANTSP30DK048520 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI JANINE A HIGGINS · 1995 to 2026
$32.6M
Center for Clinical and Translational Sciences (CCTS)UL1TR000371 · NCATS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI MCPHERSON, DAVID D · 2012 to 2016
$13.4M
Statistical Methods for Analysis of Massive Genetic and Genomic Data in Cancer ResearchR35CA197449 · NCI · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI XIHONG LIN · 2015 to 2026
$10.9M
Effect of patient-provider sexual communication adjuvant endocrine therapy adherence, sexual dysfunction management, and sexual quality of life among Black women with breast cancerR01CA218155 · NCI · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI GRAETZ, ILANA · 2017 to 2021
$2.3M
MicroRNA-based epigenetic approach to induce fetal hemoglobinR01HL144641 · NHLBI · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI STARLARD-DAVENPORT, ATHENA · 2020 to 2022
$928k
The Role of Adverse Symptoms and Clinical Response on Racial Disparity Outcomes in Breast CancerR21CA208161 · NCI · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI GRAETZ, ILANA · 2017 to 2018
$364k
NCATS NIH HHS UL1 TR000371NCI NIH HHS P30 CA008748NCI NIH HHS P30 CA013148NCI NIH HHS R01 CA218155NCI NIH HHS R21 CA208161NCI NIH HHS R35 CA197449NHLBI NIH HHS R01 HL144641NIMHD NIH HHS L60 MD008232
6 · The paper itself

Abstract

purposeOral adjuvant endocrine therapy (AET) reduces the risk of cancer recurrence and death for women with hormone receptor-positive (HR+) breast cancer. Because of adverse symptoms and socioecologic barriers, AET adherence rates are low. We conducted post hoc analyses of a randomized trial of a remote symptom and adherence monitoring app to evaluate characteristics associated with higher app use, satisfaction, and how app use was associated with AET adherence.

methodsPatients prescribed AET were randomly assigned to receive one of three intervention conditions: app, app + feedback, or enhanced usual care. Baseline and 6-month follow-up surveys, app use, and pillbox-monitored AET adherence data for app and app + feedback participants were used. Logistic regression evaluated the association between sociodemographic/clinical characteristics and app utilization and satisfaction, and how app use was associated with AET adherence (>80%).

resultsOverall, 163 women with early-stage HR+ breast cancer were included; 35.0% had high app use (≥75% of weeks enrolled). No sociodemographic characteristics were associated with app use. Satisfaction with the app was higher among those who were younger (88.9% for age 31-49 years

conclusionUse of a remote monitoring app was similar across sociodemographic characteristics, and more frequent app use was associated with a higher likelihood of 6-month AET adherence. Encouraging women to monitor medication adherence and communicate adverse symptoms could improve AET adherence.

Indexed as

Antineoplastic Agents, HormonalBreast NeoplasmsCancer SurvivorsDrug MonitoringMobile ApplicationsAdultAgedChemotherapy, AdjuvantFemaleHumansMiddle AgedAntineoplastic Agents, Hormonal

Identifiers

PMID39642329
PMCPMC11631045

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.