Evidence map›Paper›PMID 39642327›Full record

ArticleJCO precision oncology2024

Rebecca Gelfer, Aiste Gulla, Hannah L Kalvin, Yi Song, James Harding, Ghassan K Abou-Alfa, Eileen M O'Reilly, Wungki Park, Rohit Chandwani, Alice Wei and 7 more

Abstract read
In one paragraph

Article in JCO precision oncology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Trial
  2. Review
  3. Prognostic Implications of Codon-SpecificJCO precision oncology · 2026
    Article
  4. Article
  5. Review
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Rebecca GelferDepartment of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY.ORCID 0000-0002-7270-8249
Aiste GullaDepartment of Surgery, Vilnius University Hospital, Vilnius, Lithuania.
Hannah L KalvinDepartment of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY.
Yi SongDepartment of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY.ORCID 0000-0003-0125-6019
James HardingDepartment of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY.ORCID 0000-0002-7029-4310
Ghassan K Abou-AlfaDepartment of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY.ORCID 0000-0002-1522-8054
Eileen M O'ReillyDepartment of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY.ORCID 0000-0002-8076-9199
Wungki ParkDepartment of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY.ORCID 0000-0002-8006-3102
Rohit ChandwaniDepartment of Surgery, Weill Cornell Medicine, New York, NY.ORCID 0000-0003-4781-6069
Alice WeiDepartment of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY.ORCID 0000-0002-2505-959X
Peter KinghamDepartment of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY.
Jeffrey DrebinDepartment of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY.
Vinod BalachandranDepartment of Medicine, Weill Cornell Medicine, New York, NY.
Michael D'AngelicaDepartment of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY.
Kevin SoaresDepartment of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY.ORCID 0000-0002-0406-017X
Mithat GonenDepartment of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY.ORCID 0000-0001-8683-8477
William R JarnaginDepartment of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY.ORCID 0000-0002-1635-5768

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
Weill Cornell/Rockefeller/Sloan-Kettering MST ProgramT32GM007739 · NIGMS · WEILL MEDICAL COLL OF CORNELL UNIV · PI HSU, KATHARINE C · 1985 to 2023
$51.1M
Weill Cornell/Rockefeller/Sloan Kettering MST ProgramT32GM152349 · NIGMS · WEILL MEDICAL COLL OF CORNELL UNIV · PI KATHARINE C HSU · 2024 to 2026
$6.6M
Improving Outcome in Patients with Advanced Intrahepatic Cholangiocarcinoma: A Randomized Phase II Study of Gemcitabine and Oxaliplatin With or Without Regional Floxuridine (FUDR)U01CA238444 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI CERCEK, ANDREA, IACOBUZIO-DONAHUE, CHRISTINE A · 2020 to 2024
$3.3M
Deformation Corrected Image Guided Laparoscopic Liver SurgeryR01EB027498 · NIBIB · VANDERBILT UNIVERSITY · PI JARNAGIN, WILLIAM ROBERT, MIGA, MICHAEL IAN · 2019 to 2022
$2.5M
Defining the oncogenic potential and therapeutic dependencies of PDAC-associated KRAS variantsR01CA290616 · NCI · WEILL MEDICAL COLL OF CORNELL UNIV · PI Rohit Chandwani, LUKAS Edward DOW · 2025 to 2026
$1.3M
Multidisciplinary Training in Gastrointestinal CancersT32CA285274 · NCI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Julian Abrams, Anil K Rustgi · 2024 to 2026
$897k
Characterizing Oncogenic Nras in IDH1 Mutant AML Leukemogenesis and Therapeutic ResponsivenessF30CA284575 · NCI · WEILL MEDICAL COLL OF CORNELL UNIV · PI Rebecca Gelfer · 2024 to 2026
$164k
NCI NIH HHS F30 CA284575NCI NIH HHS P30 CA008748NCI NIH HHS R01 CA290616NCI NIH HHS T32 CA285274NCI NIH HHS U01 CA238444NIBIB NIH HHS R01 EB027498NIGMS NIH HHS T32 GM007739NIGMS NIH HHS T32 GM152349
6 · The paper itself

Abstract

purpose

methodsIn this cross-sectional, single-institution study at Memorial Sloan Kettering, tumors from 985 patients treated between 2004 and 2022 with IHC, EHC, and GB who underwent either curative-intent resection or were treated with chemotherapy for unresectable disease were used for targeted sequencing.

resultsOf the 985 patients sequenced, 15% had a

conclusionThe adverse impact of

Indexed as

Biliary Tract NeoplasmsProto-Oncogene Proteins p21(ras)AgedCholangiocarcinomaCross-Sectional StudiesFemaleHumansMaleMiddle AgedMutationKRAS protein, humanProto-Oncogene Proteins p21(ras)

Identifiers

PMID39642327
PMCPMC12305477

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.