Evidence map›Paper›PMID 39642224›Full record

ArticleScience advances2024

An extragenital cell population contributes to urethra closure during mouse penis development.

Ciro Maurizio Amato, Xin Xu, Humphrey Hung-Chang Yao

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science advances, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Epigenetic Signatures in Hypospadias: Systematic Review.Journal of Indian Association of Pediatric Surgeons
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

Ciro Maurizio AmatoReproductive Developmental Biology Group, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA.ORCID 0000-0001-5090-2027
Xin XuEpigenetics and Stem Cell Biology Laboratory, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA.ORCID 0000-0003-2294-0047
Humphrey Hung-Chang YaoReproductive Developmental Biology Group, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA.ORCID 0000-0003-2944-8469

Funding

Defining the role of Sf1 in urethral closureR00DK132460 · NIDDK · UNIVERSITY OF MISSOURI-COLUMBIA · PI Ciro Maurizio Amato · 2024 to 2026
$736k
NIDDK NIH HHS K99 DK132460NIDDK NIH HHS R00 DK132460
6 · The paper itself

Abstract

The penis, the organ that bears reproductive and psychological importance, is susceptible to birth defects such as hypospadias or incomplete closure of urethra along the penis shaft. We discover that proper urethral closure in mouse embryos requires a unique mesenchymal cell population originated from outside of the penis. These "extragenital" cells, marked by a lineage marker

Indexed as

HypospadiasPenisUrethraAnimalsCell DifferentiationMaleMesenchymal Stem CellsMiceOrganogenesis

Identifiers

PMID39642224
PMCPMC11623300

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.