Evidence map›Paper›PMID 39642218›Full record

ArticleScience advances2024

Sex-dimorphic tumor growth is regulated by tumor microenvironmental and systemic signals.

Xianfeng Wang, Hongcun Bao, Yi-Chun Huang, Anindita Barua, Chun-Ming Lai, Jie Sun, Youfang Zhou, Fei Cong, Shangyu Gong, Chih-Hsuan Chang and 1 more

Abstract read
In one paragraph

Article in Science advances, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Macrophage restriction inScience advances · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Leptin Acts as a Peripheral Tropic Signal to Tune Steroidogenesis.bioRxiv : the preprint server for biology · 2026
    Article
  7. Review
  8. Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Xianfeng WangDepartment of Biochemistry and Molecular Biology, Tulane University School of Medicine, Louisiana Cancer Research Center, New Orleans, LA 70112, USA.ORCID 0000-0001-7207-7865
Hongcun BaoDepartment of Biochemistry and Molecular Biology, Tulane University School of Medicine, Louisiana Cancer Research Center, New Orleans, LA 70112, USA.ORCID 0009-0009-9445-3978
Yi-Chun HuangDepartment of Biochemistry and Molecular Biology, Tulane University School of Medicine, Louisiana Cancer Research Center, New Orleans, LA 70112, USA.ORCID 0000-0001-6409-485X
Anindita BaruaDepartment of Biochemistry and Molecular Biology, Tulane University School of Medicine, Louisiana Cancer Research Center, New Orleans, LA 70112, USA.
Chun-Ming LaiDepartment of Biochemistry and Molecular Biology, Tulane University School of Medicine, Louisiana Cancer Research Center, New Orleans, LA 70112, USA.
Jie SunDepartment of Biochemistry and Molecular Biology, Tulane University School of Medicine, Louisiana Cancer Research Center, New Orleans, LA 70112, USA.ORCID 0000-0001-5210-6673
Youfang ZhouDepartment of Biochemistry and Molecular Biology, Tulane University School of Medicine, Louisiana Cancer Research Center, New Orleans, LA 70112, USA.ORCID 0000-0001-6088-765X
Fei CongDepartment of Biochemistry and Molecular Biology, Tulane University School of Medicine, Louisiana Cancer Research Center, New Orleans, LA 70112, USA.ORCID 0000-0003-1362-4755
Shangyu GongDepartment of Biochemistry and Molecular Biology, Tulane University School of Medicine, Louisiana Cancer Research Center, New Orleans, LA 70112, USA.
Chih-Hsuan ChangDepartment of Biochemistry and Molecular Biology, Tulane University School of Medicine, Louisiana Cancer Research Center, New Orleans, LA 70112, USA.ORCID 0009-0009-9448-247X
Wu-Min DengDepartment of Biochemistry and Molecular Biology, Tulane University School of Medicine, Louisiana Cancer Research Center, New Orleans, LA 70112, USA.ORCID 0000-0002-9098-9769

Funding

Notch signaling and germline-soma interactions in the Drosophila ovarian modelR01GM072562 · NIGMS · TULANE UNIVERSITY OF LOUISIANA · PI DENG, WU-MIN · 2006 to 2025
$5.6M
Tissue Microenvironment ant Tumor Hotspots in DrosophilaR01CA227789 · NCI · TULANE UNIVERSITY OF LOUISIANA · PI DENG, WU-MIN · 2019 to 2023
$1.7M
Mechanistic investigation of malignant rhabdoid childhood tumor using the Drosophila modelR01CA224381 · NCI · TULANE UNIVERSITY OF LOUISIANA · PI DENG, WU-MIN · 2018 to 2022
$1.7M
Polyploidy and Sex Dimorphism in a Drosophila Tumor ModelR01CA287524 · NCI · TULANE UNIVERSITY OF LOUISIANA · PI Wu-Min Deng · 2024 to 2026
$1.7M
NCI NIH HHS R01 CA224381NCI NIH HHS R01 CA227789NCI NIH HHS R01 CA287524NIGMS NIH HHS R01 GM072562
6 · The paper itself

Abstract

Tumor growth and progression involve coordinated regulation by internal, microenvironmental, and systemic signals and often display conspicuous sexual dimorphism. The mechanisms governing the integration and coordination of these signals, along with their sex-based differences, remain largely unknown. Using a

Indexed as

Drosophila ProteinsSex CharacteristicsSignal TransductionTumor MicroenvironmentAnimalsDrosophila melanogasterFemaleHemocytesInsulinMaleNeoplasmsDrosophila ProteinsInsulin

Identifiers

PMID39642218
PMCPMC11623276

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.