Evidence map›Paper›PMID 39642214›Full record

ArticleScience advances2024

Inhibitors of malaria parasite cyclic nucleotide phosphodiesterases block asexual blood-stage development and mosquito transmission.

Paula-Josefina Gomez-Gonzalez, Antima Gupta, Laura G Drought, Avnish Patel, John Okombo, Mariëtte van der Watt, Ryan Walker-Gray, Kyra A Schindler, Anna Y Burkhard, Tomas Yeo and 37 more

Abstract read
In one paragraph

Article in Science advances, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

47 authors.

Paula-Josefina Gomez-GonzalezFaculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, London, UK.ORCID 0000-0002-3670-8786
Antima GuptaFaculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, London, UK.ORCID 0009-0009-2145-4179
Laura G DroughtFaculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, London, UK.
Avnish PatelFaculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, London, UK.ORCID 0000-0002-3608-3405
John OkomboDepartment of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY, USA.ORCID 0000-0001-8680-2351
Mariëtte van der WattDepartment of Biochemistry, Genetics and Microbiology, University of Pretoria, Pretoria, South Africa.ORCID 0000-0002-9933-8647
Ryan Walker-GrayFaculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, London, UK.
Kyra A SchindlerDepartment of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY, USA.ORCID 0000-0002-4406-9160
Anna Y BurkhardDepartment of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY, USA.
Tomas YeoDepartment of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY, USA.ORCID 0000-0003-2923-6060
Sunil K NarwalDepartment of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY, USA.ORCID 0000-0001-5476-9753
Talia S BloxhamCenter for Malaria Therapeutics and Antimicrobial Resistance, Columbia University Irving Medical Center, New York, NY, USA.ORCID 0009-0002-8613-0457
Christian FlueckFaculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, London, UK.
Eloise M WalkerFaculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, London, UK.
Joshua A ReyFaculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, London, UK.
Kate J FairhurstDepartment of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY, USA.
Janette ReaderDepartment of Biochemistry, Genetics and Microbiology, University of Pretoria, Pretoria, South Africa.ORCID 0000-0001-9026-0583
Heekuk ParkCenter for Malaria Therapeutics and Antimicrobial Resistance, Columbia University Irving Medical Center, New York, NY, USA.ORCID 0000-0001-5815-9717
Harry G PollardFaculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, London, UK.
Lindsay B StewartFaculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, London, UK.ORCID 0000-0002-9003-0160
Luke Brandner-GarrodFaculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, London, UK.
Mojca KristanFaculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, London, UK.ORCID 0000-0002-0363-8558
Geert-Jan SterkVrije Universiteit Amsterdam, Amsterdam, Netherlands.
Youri M van NulandTropIQ Health Sciences, Nijmegen, Netherlands.ORCID 0000-0002-2481-2754
Emilia MankoFaculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, London, UK.ORCID 0000-0001-7405-6523
Donelly A van SchalkwykFaculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, London, UK.ORCID 0000-0002-7375-3439
Yang ZhengVrije Universiteit Amsterdam, Amsterdam, Netherlands.ORCID 0000-0001-7035-8807
Rob LeursVrije Universiteit Amsterdam, Amsterdam, Netherlands.ORCID 0000-0003-1354-2848
Koen J DecheringTropIQ Health Sciences, Nijmegen, Netherlands.ORCID 0000-0002-8124-4634
Anna Caroline C AguiarFederal University of São Paulo, São Paulo, Brazil.ORCID 0000-0003-0139-8279
Rafael V C GuidoSao Carlos Institute of Physics, University of São Paulo, São Carlos, Brazil.ORCID 0000-0002-7187-0818
Dhelio B PereiraResearch Center for Tropical Medicine of Rondonia, Porto Velho, Brazil.ORCID 0000-0002-7761-5498
Patrick K TumwebazeInfectious Diseases Research Collaboration, Kampala, Uganda.
Samuel L NosbyaInfectious Diseases Research Collaboration, Kampala, Uganda.
Philip J RosenthalUniversity of California, San Francisco, CA, USA.ORCID 0000-0002-7953-7622
Roland A CooperDominican University of California, San Rafael, CA, USA.
Mike PalmerSalvensis, Sandwich, UK.
Tanya ParkinsonSalvensis, Sandwich, UK.
Jeremy N BurrowsMedicines for Malaria Venture, Geneva, Switzerland.ORCID 0000-0001-8448-6068
Anne-Catrin UhlemannCenter for Malaria Therapeutics and Antimicrobial Resistance, Columbia University Irving Medical Center, New York, NY, USA.ORCID 0000-0002-9798-4768
Lyn-Marié BirkholtzDepartment of Biochemistry, Genetics and Microbiology, University of Pretoria, Pretoria, South Africa.ORCID 0000-0001-5888-2905
Jennifer L Small-SaundersCenter for Malaria Therapeutics and Antimicrobial Resistance, Columbia University Irving Medical Center, New York, NY, USA.ORCID 0000-0001-6064-2249
James DuffyMedicines for Malaria Venture, Geneva, Switzerland.
David A FidockDepartment of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY, USA.ORCID 0000-0001-6753-8938
Alan BrownSalvensis, Sandwich, UK.
Mark GardnerSalvensis, Sandwich, UK.ORCID 0000-0002-9322-1181
David A BakerFaculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, London, UK.ORCID 0000-0002-5490-8933

Funding

Mechanisms of varied sensitivity of P. falciparum field isolates to the antimalarial drug pipelineR01AI139179 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Philip Jon Rosenthal · 2018 to 2026
$6.3M
Defining the complex genetic basis of Plasmodium falciparum resistance to artemisinin and quinine and identifying resistance-refractory therapeuticsR01AI185559 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI David A Fidock · 2024 to 2026
$1.9M
tRNA modification reprogramming in artemisinin-resistant Plasmodium falciparum: An epigenetic driver of resistance?K08AI163497 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI SMALL-SAUNDERS, JENNIFER L. · 2021 to 2024
$769k
Gates Foundation INV-033538NIAID NIH HHS K08 AI163497NIAID NIH HHS R01 AI139179NIAID NIH HHS R01 AI185559Wellcome Trust
6 · The paper itself

Abstract

Cyclic nucleotide-dependent phosphodiesterases (PDEs) play essential roles in regulating the malaria parasite life cycle, suggesting that they may be promising antimalarial drug targets. PDE inhibitors are used safely to treat a range of noninfectious human disorders. Here, we report three subseries of fast-acting and potent

Indexed as

AntimalarialsPhosphodiesterase InhibitorsPlasmodium falciparum3',5'-Cyclic-AMP PhosphodiesterasesAnimalsCulicidaeCyclic AMP-Dependent Protein KinasesHumansLife Cycle StagesMalaria, FalciparumPhosphoric Diester HydrolasesProtozoan Proteins3',5'-Cyclic-AMP PhosphodiesterasesAntimalarialsCyclic AMP-Dependent Protein KinasesPhosphodiesterase InhibitorsPhosphoric Diester HydrolasesProtozoan Proteins

Identifiers

PMID39642214
PMCPMC11623267

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.