Evidence map›Paper›PMID 39642202›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2024

Understanding paralogous epilepsy-associated GABA

Anthony S H Kan, Ali S Kusay, Nazanin A Mohammadi, Susan X N Lin, Vivian W Y Liao, Gaetan Lesca, Sabrine Souci, Mathieu Milh, Palle Christophersen, Mary Chebib and 4 more

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Article
  6. Direct modulation of human GABA-A αFrontiers in neuroscience · 2026
    Review
  7. Article
  8. Article
  9. Massive Activation of GABABiomolecules · 2025
    Review
  10. Transcriptomic Profiling of Zebrafish Mutant forInternational journal of molecular sciences · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Anthony S H Kan *School of Medical Sciences, Faculty of Medicine and Health, Brain and Mind Centre, The University of Sydney, Sydney, NSW 2006, Australia.ORCID 0009-0008-3563-7112
Ali S Kusay *School of Medical Sciences, Faculty of Medicine and Health, Brain and Mind Centre, The University of Sydney, Sydney, NSW 2006, Australia.
Nazanin A Mohammadi *Department of Epilepsy Genetics and Personalized Treatment, Danish Epilepsy Center Filadelfia, Member of the European Reference Network EpiCARE, Dianalund DK-4293, Denmark.
Susan X N LinSchool of Medical Sciences, Faculty of Medicine and Health, Brain and Mind Centre, The University of Sydney, Sydney, NSW 2006, Australia.
Vivian W Y LiaoSchool of Medical Sciences, Faculty of Medicine and Health, Brain and Mind Centre, The University of Sydney, Sydney, NSW 2006, Australia.
Gaetan LescaDepartment of Medical Genetics, Member of the European Reference Network EpiCARE, Hospices Civils de Lyon, Lyon 69002, France.
Sabrine SouciDepartment of Neurology, Hospices Civils de Lyon, Lyon Sud University Hospital, Pierre Bénite 69495, France.
Mathieu MilhDepartment of Pediatric Neurology, Assistance Publique - Hôpitaux de Marseille, La Timone Children's Hospital, Marseille 13005, France.
Palle ChristophersenSaniona A/S, Ballerup DK-2750, Denmark.
Mary ChebibSchool of Medical Sciences, Faculty of Medicine and Health, Brain and Mind Centre, The University of Sydney, Sydney, NSW 2006, Australia.
Rikke S MøllerDepartment of Epilepsy Genetics and Personalized Treatment, Danish Epilepsy Center Filadelfia, Member of the European Reference Network EpiCARE, Dianalund DK-4293, Denmark.
Nathan L AbsalomSchool of Medical Sciences, Faculty of Medicine and Health, Brain and Mind Centre, The University of Sydney, Sydney, NSW 2006, Australia.
Anders A JensenDepartment of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen DK-2100, Denmark.ORCID 0000-0002-7927-5052
Philip K AhringSchool of Medical Sciences, Faculty of Medicine and Health, Brain and Mind Centre, The University of Sydney, Sydney, NSW 2006, Australia.ORCID 0000-0003-1807-3331

Funding

DHAC | National Health and Medical Research Council (NHMRC) APP2019780Lundbeck Foundation (Lundbeckfonden) R383-2022-276Novo Nordisk Fonden (NNF) NNF19OC0058749
6 · The paper itself

Abstract

Recent discoveries have revealed that genetic variants in γ-aminobutyric acid type A (GABA

Indexed as

EpilepsyReceptors, GABA-AChildChild, PreschoolFemaleGain of Function MutationHumansInfantMaleMolecular Dynamics SimulationMutation, MissenseProtein SubunitsGABRA1 protein, humanGABRB2 protein, humanGABRB3 protein, humanGABRG2 protein, humanProtein SubunitsReceptors, GABA-AepilepsyGABRA1GABRB3GABRG2neurodevelopmental disorders

Identifiers

PMID39642202
PMCPMC11648851

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.