Evidence map›Paper›PMID 39642058›Full record

ArticleJournal of the American Chemical Society2024

Engineering the Reaction Pathway of a Non-heme Iron Oxygenase Using Ancestral Sequence Reconstruction.

Di Yang, Chang-Hwa Chiang, Taveechai Wititsuwannakul, Charles L Brooks, Paul M Zimmerman, Alison R H Narayan

Abstract read
In one paragraph

Article in Journal of the American Chemical Society, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Di YangDepartment of Chemistry, University of Michigan, Ann Arbor, Michigan 48109, United States.
Chang-Hwa ChiangDepartment of Chemistry, University of Michigan, Ann Arbor, Michigan 48109, United States.ORCID 0000-0003-1363-9148
Taveechai WititsuwannakulDepartment of Chemistry, University of Michigan, Ann Arbor, Michigan 48109, United States.ORCID 0000-0002-3752-3089
Charles L BrooksDepartment of Chemistry, University of Michigan, Ann Arbor, Michigan 48109, United States.ORCID 0000-0002-8149-5417
Paul M ZimmermanDepartment of Chemistry, University of Michigan, Ann Arbor, Michigan 48109, United States.ORCID 0000-0002-7444-1314
Alison R H NarayanDepartment of Chemistry, University of Michigan, Ann Arbor, Michigan 48109, United States.ORCID 0000-0001-8290-0077

Funding

Theory and Modeling of Biomolecules and their Interactions - Equipment SupplementR35GM130587 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CHARLES L BROOKS · 2019 to 2026
$6.9M
Undergrad Supplement: Expanding the synthetic utility of natural product biosynthetic enzymesR35GM124880 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Alison Narayan · 2017 to 2026
$4.5M
Mechanism-Guided Catalyst Development through Reaction Discovery Simulation - Equipment SupplementR35GM128830 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ZIMMERMAN, PAUL · 2018 to 2022
$1.9M
NIGMS NIH HHS R35 GM124880NIGMS NIH HHS R35 GM128830NIGMS NIH HHS R35 GM130587
6 · The paper itself

Abstract

Non-heme iron (Fe

Indexed as

OxygenasesProtein EngineeringCatalytic DomainKetoglutaric AcidsModels, MolecularMutagenesis, Site-DirectedNonheme Iron ProteinsQuantum TheoryKetoglutaric AcidsNonheme Iron ProteinsOxygenases

Identifiers

PMID39642058
PMCPMC11957380

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.