Evidence map›Paper›PMID 39641974›Full record

ArticleeLife2024

Lineage-specific intersection of endothelin and GDNF signaling in enteric nervous system development.

Denise M Poltavski, Alexander T Cunha, Jaime Tan, Henry M Sucov, Takako Makita

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in eLife, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Denise M Poltavski *Department of Regenerative Medicine and Cell Biology, Medical University of South Carolina, Charleston, United States.ORCID https://orcid.org/0009-0002-7377-4915
Alexander T Cunha *Department of Regenerative Medicine and Cell Biology, Medical University of South Carolina, Charleston, United States.ORCID https://orcid.org/0000-0002-7178-8152
Jaime TanDepartment of Regenerative Medicine and Cell Biology, Medical University of South Carolina, Charleston, United States.ORCID https://orcid.org/0009-0008-3063-8060
Henry M SucovDepartment of Regenerative Medicine and Cell Biology, Medical University of South Carolina, Charleston, United States.ORCID https://orcid.org/0000-0002-3792-3795
Takako MakitaDepartment of Regenerative Medicine and Cell Biology, Medical University of South Carolina, Charleston, United States.ORCID https://orcid.org/0000-0002-5598-5690

Funding

Placode lineage contribution to Hirschsprung's diseaseR01NS084121 · NINDS · CHILDREN'S HOSPITAL OF LOS ANGELES · PI MAKITA, TAKAKO · 2013 to 2017
$1.8M
NINDS NIH HHS NS084121NINDS NIH HHS R01 NS084121
6 · The paper itself

Abstract

Two major ligand-receptor signaling axes - endothelin Edn3 and its receptor Ednrb, and glial-derived neurotrophic factor (GDNF) and its receptor Ret - are required for migration of enteric nervous system (ENS) progenitors to the hindgut. Mutations in either component cause colonic aganglionosis, also called Hirschsprung disease. Here, we have used Wnt1Cre and Pax2Cre in mice to show that these driver lines label distinct ENS lineages during progenitor migration and in their terminal hindgut fates. Both Cre lines result in Hirschsprung disease when combined with conditional

Indexed as

Ectodermal PlacodesEnteric Nervous SystemNeural CrestAnimalsCell LineageCell MovementEndothelin-3Gastrointestinal MotilityGlial Cell Line-Derived Neurotrophic FactorMiceMice, Inbred ICRPAX2 Transcription FactorProto-Oncogene Proteins c-retReceptor, Endothelin BWnt1 ProteinEdn3 protein, mouseEDNRB protein, mouseEndothelin-3Gdnf protein, mouseGlial Cell Line-Derived Neurotrophic FactorPax2 protein, mousePAX2 Transcription FactorProto-Oncogene Proteins c-retReceptor, Endothelin BWnt1 ProteinWnt1 protein, mousedevelopmental biologyenteric nervous systemHirschsprung diseasemouseneural crestneuroscienceplacode

Identifiers

PMID39641974
PMCPMC11623925

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.