Evidence map›Paper›PMID 39641922›Full record

ArticleInternational clinical psychopharmacology2025

Differences in emotion recognition between nonimmersive versus immersive virtual reality: preliminary findings in schizophrenia and bipolar disorder.

Mauro Scala, Daniel Sánchez-Reolid, Roberto Sánchez-Reolid, Patricia Fernández-Sotos, Verónica Romero-Ferreiro, Miguel Ángel Alvarez-Mon, Guillermo Lahera, Giuseppe Fanelli, Alessandro Serretti, Chiara Fabbri and 2 more

Abstract read
In one paragraph

Article in International clinical psychopharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Personality domains in early stages of psychosis: a systematic review and meta-analysis.European archives of psychiatry and clinical neuroscience · 2026
    Pooled it
  2. Neural correlates of social cognition in BPD: a review of MRI evidence.European archives of psychiatry and clinical neuroscience · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Mauro ScalaDepartment of Biomedical and Neuromotor Sciences (DIBINEM), University of Bologna, Bologna, Italy.
Daniel Sánchez-ReolidInstituto de Investigación en Informática de Albacete, Universidad de Castilla-La Mancha (UCLM), Albacete.
Roberto Sánchez-ReolidInstituto de Investigación en Informática de Albacete, Universidad de Castilla-La Mancha (UCLM), Albacete.
Patricia Fernández-SotosCIBERSAM-ISCIII (Biomedical Research Networking Centre in Mental Health), Madrid.
Verónica Romero-FerreiroDepartment of Psychiatry, Health Research Institute Hospital 12 de Octubre (imas12).
Miguel Ángel Alvarez-MonCIBERSAM-ISCIII (Biomedical Research Networking Centre in Mental Health), Madrid.
Guillermo LaheraCIBERSAM-ISCIII (Biomedical Research Networking Centre in Mental Health), Madrid.
Giuseppe FanelliDepartment of Biomedical and Neuromotor Sciences (DIBINEM), University of Bologna, Bologna, Italy.
Alessandro SerrettiDepartment of Medicine and Surgery, Kore University of Enna, Enna.
Chiara FabbriDepartment of Biomedical and Neuromotor Sciences (DIBINEM), University of Bologna, Bologna, Italy.
Antonio Fernández-CaballeroInstituto de Investigación en Informática de Albacete, Universidad de Castilla-La Mancha (UCLM), Albacete.
Roberto Rodriguez-JimenezDepartment of Psychiatry, Health Research Institute Hospital 12 de Octubre (imas12).

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Deficits in social cognition may impair emotional processing and facial emotional recognition (FER) in patients with bipolar disorder (BD) and schizophrenia. FER is generally explored using photographs or images of static faces that do not fully capture the complexity of real-life facial stimuli. To overcome this limitation, we developed a set of dynamic virtual faces depicting six basic emotions (i.e. happiness, sadness, anger, fear, disgust, and surprise) and a neutral expression suitable for presentation in immersive and nonimmersive virtual realities. This study presents preliminary findings on the differences in FER accuracy from a frontal view between immersive and nonimmersive virtual realities among patients experiencing a relapse of schizophrenia ( n  = 10), a manic phase of BD ( n  = 10), and a group of healthy controls (HCs) ( n  = 10). As a secondary objective, we compare the FER accuracy across these three groups. Patients with schizophrenia and BD showed similar accuracy in recognizing emotions in immersive and nonimmersive virtual reality settings. However, patients with schizophrenia exhibited lower FER accuracy than HCs in both settings. Individuals with BD showed intermediate accuracy between those with schizophrenia and HCs, although these differences were not statistically significant. Notably, recognition of negative emotions was significantly impaired in both groups of patients.

Indexed as

Bipolar DisorderEmotionsFacial RecognitionRecognition, PsychologySchizophreniaSchizophrenic PsychologyVirtual RealityAdultFacial ExpressionFemaleHumansMaleMiddle AgedYoung Adultdynamic virtual humansemotion recognitionfacial affect recognitionmaniapsychosissocial cognition

Identifiers

PMID39641922
PMCPMC12309510

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.