Evidence map›Paper›PMID 39641891›Full record

ArticleThe international journal of cardiovascular imaging2025

Accuracy of dynamic stress CT myocardial perfusion in patients with suspected non-ST elevation myocardial infarction.

M J Hinderks, O Sliwicka, K Salah, I Sechopoulos, M Brink, A Cetinyurek-Yavuz, W M Prokop, R Nijveldt, J Habets, P Damman

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in The international journal of cardiovascular imaging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

M J Hinderks *Department of Cardiology, Radboud University Medical Center, Nijmegen, The Netherlands.
O Sliwicka *Department of Medical Imaging, Radboud University Medical Center, Nijmegen, The Netherlands.
K SalahDepartment of Medical Imaging, Radboud University Medical Center, Nijmegen, The Netherlands.
I SechopoulosDepartment of Medical Imaging, Radboud University Medical Center, Nijmegen, The Netherlands.
M BrinkDepartment of Medical Imaging, Radboud University Medical Center, Nijmegen, The Netherlands.
A Cetinyurek-YavuzDepartment of Health Evidence, Radboud University Medical Center, Nijmegen, The Netherlands.
W M ProkopDepartment of Medical Imaging, Radboud University Medical Center, Nijmegen, The Netherlands.
R NijveldtDepartment of Cardiology, Radboud University Medical Center, Nijmegen, The Netherlands.
J HabetsDepartment of Medical Imaging, Radboud University Medical Center, Nijmegen, The Netherlands.
P DammanDepartment of Cardiology, Radboud University Medical Center, Nijmegen, The Netherlands. peter.damman@radboudumc.nl.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Coronary CT angiography (CCTA) and dynamic stress CT myocardial perfusion (CT-MPI) are established modalities in the analysis of patients with chronic coronary syndromes. Their role in patients with suspected non-ST elevation myocardial infarction (NSTEMI) is unknown. CCTA with CT-MPI might assist in the triage of NSTEMI patients to the Cath lab. We investigated the correlation of significant epicardial lesions by CT-MPI in addition to CCTA compared to invasive coronary angiography (ICA) with fractional flow reserve (FFR) in patients with NSTEMI. Twenty NSTEMI patients scheduled for ICA were enrolled in this study with planned ICA. CCTA and CT-MPI was performed pre-ICA. For each coronary artery, the presence or absence of significant lesions was interpreted by CCTA with CT-MPI, using an FFR of ≤ 0.8 or angiographic culprit (stenosis > 90%, suspected plaque rupture) as reference. The main outcome was the per-vessel correlation. Sixteen out of 20 patients had a culprit lesion that required immediate revascularization. CCTA with ≥ 50% stenosis demonstrated a per vessel sensitivity and specificity for the detection of significant stenosis of respectively 100% (95% CI: 86-100%) and 75% (95% CI: 58-88%). CCTA with CT-MPI showed a lower sensitivity 90% (95% CI: 70-99%) but higher specificity of 100% (95% CI: 90-100%). CCTA with CT-MPI exhibits a strong correlation for identifying significant CAD in patients with NSTEMI. Thereby, it might assist in the triage of ICA in NSTEMI patients.

Indexed as

Computed Tomography AngiographyCoronary AngiographyCoronary Artery DiseaseCoronary StenosisCoronary VesselsMultidetector Computed TomographyMyocardial Perfusion ImagingNon-ST Elevated Myocardial InfarctionAgedFemaleFractional Flow Reserve, MyocardialHumansMaleMiddle AgedPredictive Value of TestsReproducibility of ResultsCCTACT-MPINSTEMI

Identifiers

PMID39641891
PMCPMC11742333

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.