Evidence map›Paper›PMID 39641887›Full record

ArticleChinese journal of integrative medicine2025

Zedoarondiol Inhibits Neovascularization in Atherosclerotic Plaques of ApoE

Bei-Li Xie, Bo-Ce Song, Ming-Wang Liu, Wei Wen, Yu-Xin Yan, Meng-Jie Gao, Lu-Lian Jiang, Zhi-Die Jin, Lin Yang, Jian-Gang Liu and 2 more

Abstract read
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In one paragraph

Article in Chinese journal of integrative medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Bei-Li XieCardiovascular Department, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, 100091, China.
Bo-Ce SongCardiovascular Department, Beijing Hospital of Integrated Chinese and Western Medicine, Beijing, 100091, China.
Ming-Wang LiuCardiovascular Department, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, 100091, China.
Wei WenCardiovascular Department, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, 100091, China.
Yu-Xin YanCardiovascular Department, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, 100091, China.
Meng-Jie GaoGraduate School of Beijing University of Chinese Medicine, Beijing, 100091, China.
Lu-Lian JiangGraduate School of Beijing University of Chinese Medicine, Beijing, 100091, China.
Zhi-Die JinCardiovascular Department, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, 100091, China.
Lin YangCardiovascular Department, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, 100091, China.
Jian-Gang LiuCardiovascular Department, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, 100091, China.
Da-Zhuo ShiCardiovascular Department, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, 100091, China.
Fu-Hai ZhaoCardiovascular Department, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, 100091, China. 13911134962@163.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo investigate the effect of zedoarondiol on neovascularization of atherosclerotic (AS) plaque by exosomes experiment.

methodsApoE

resultsAnimal experiments showed that after treating with zedoarondiol, the neovascularization density in plaques of AS mice was significantly reduced, THBS-1 and CD36 increased, the platelet activation rate was markedly reduced, and the miR-let-7a level in Pexo was reduced (P<0.01). In vitro experiments, the platelet activation rate and miR-let-7a levels in Pexo were significantly reduced after zedoarondiol's intervention. Cell experiments showed that after Pexo's intervention, the tube length increased, and the transfection of miR-let-7a minics further increased the tube length of cells, while reducing the expressions of THBS-1 and CD36.

conclusionZedoarondiol has the effect of inhibiting neovascularization within plaque in AS mice, and its mechanism may be potentially related to inhibiting platelet activation and reducing the Pexo-derived miRNA-let-7a level.

Indexed as

Apolipoproteins EBlood PlateletsExosomesMicroRNAsNeovascularization, PathologicPlaque, AtheroscleroticAnimalsCD36 AntigensHumansHuman Umbilical Vein Endothelial CellsMaleMiceMice, Inbred C57BLPlatelet ActivationThrombospondin 1Apolipoproteins ECD36 AntigensMicroRNAsmirnlet7 microRNA, mouseThrombospondin 1atherosclerosisexosomesmiR-let-7aneovascularizationthrombospondin 1zedoarondiol

Identifiers

PMID39641887

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.