Evidence map›Paper›PMID 39641831›Full record

ArticleMikrochimica acta2024

A facile optical fiber-embedded microfluidic biochip for rapid and sensitive detection of microRNA-let-7a in serum.

Yongkai Lu, Jiaxin Xu, Siyan Liu, Baochun Tian, Feng Long

Abstract read
PubMed Publisher
In one paragraph

Article in Mikrochimica acta, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Yongkai LuSchool of Chemistry and Life Resources, Renmin University of China, Beijing, 100872, China.
Jiaxin XuSchool of Chemistry and Life Resources, Renmin University of China, Beijing, 100872, China.
Siyan LiuSchool of Chemistry and Life Resources, Renmin University of China, Beijing, 100872, China.
Baochun TianBeijing Daxing Xinkang Hospital, Beijing, 102600, China.
Feng LongSchool of Chemistry and Life Resources, Renmin University of China, Beijing, 100872, China. longf04@ruc.edu.cn.

Funding

Natural Science Foundation of Beijing Municipality 8242031
6 · The paper itself

Abstract

A novel hybridization chain reaction (HCR) powered optical fiber-embedded microfluidic biochip (HCR-FMB) has been constructed for ultrafast and sensitive detection of lethal-7a (let-7a) in serum. By integrating HCR, fluorescence energy resonant transfer, and evanescent wave fluorescence principle, the HCR-FMB enables detecting let-7a with satisfactory limit of detection of 100.0 pM within 6 min at room temperature, and demonstrates excellent specificity. The HCR-FMB can directly detect let-7a in serum with high sensitivity and without any pre-treatment, and good recoveries were observed for let-7a in serum samples, demonstrating their potential application to the analysis of serum samples. The HCR-FMB exhibits several advantages, including rapidity, enzyme-free, miniaturization, ease-of-operation, field-deployment applicability, minimal-equipment, and cost-effectiveness. The HCR-FMB can be considered a revolutionary detection device that rapidly adapts and deploys in various settings, especially in low medical resource regions.

Indexed as

Limit of DetectionMicroRNAsOptical FibersBiosensing TechniquesFluorescence Resonance Energy TransferHumansLab-On-A-Chip DevicesMicrofluidic Analytical TechniquesNucleic Acid HybridizationMicroRNAsmirnlet7 microRNA, humanCancer diagnosisFiber-optic sensorFluorescenceLethal-7aMicrofluidic biochipPoint-of-care testing

Identifiers

PMID39641831

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.