Evidence map›Paper›PMID 39641830›Full record

ArticleJournal of molecular histology2024

Loss of GATAD1 in cardiomyocyte does not cause cardiomyopathy in mice.

Jing Pang, Siting Zhu, Melody Shyy, Janelle Duong, Tiana Tran, Emily Sanchez-Garcia, Chao Chen, Yusu Gu, Xi Fang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of molecular histology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jing PangDepartment of Medicine, Division of Cardiovascular Medicine, University of California San Diego, 9500 Gilman Dr., Mail Code 0613-C, La Jolla, CA, 92093, USA.
Siting ZhuDepartment of Medicine, Division of Cardiovascular Medicine, University of California San Diego, 9500 Gilman Dr., Mail Code 0613-C, La Jolla, CA, 92093, USA.
Melody ShyyDepartment of Medicine, Division of Cardiovascular Medicine, University of California San Diego, 9500 Gilman Dr., Mail Code 0613-C, La Jolla, CA, 92093, USA.
Janelle DuongDepartment of Medicine, Division of Cardiovascular Medicine, University of California San Diego, 9500 Gilman Dr., Mail Code 0613-C, La Jolla, CA, 92093, USA.
Tiana TranDepartment of Medicine, Division of Cardiovascular Medicine, University of California San Diego, 9500 Gilman Dr., Mail Code 0613-C, La Jolla, CA, 92093, USA.
Emily Sanchez-GarciaDepartment of Medicine, Division of Cardiovascular Medicine, University of California San Diego, 9500 Gilman Dr., Mail Code 0613-C, La Jolla, CA, 92093, USA.
Chao ChenDepartment of Medicine, Division of Cardiovascular Medicine, University of California San Diego, 9500 Gilman Dr., Mail Code 0613-C, La Jolla, CA, 92093, USA.
Yusu GuDepartment of Medicine, Division of Cardiovascular Medicine, University of California San Diego, 9500 Gilman Dr., Mail Code 0613-C, La Jolla, CA, 92093, USA.
Xi FangDepartment of Medicine, Division of Cardiovascular Medicine, University of California San Diego, 9500 Gilman Dr., Mail Code 0613-C, La Jolla, CA, 92093, USA. xifang@ucsd.edu.

Funding

U of Calif, San Diego Neuroscience Microscopy ImagingP30NS047101 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GLEESON, JOSEPH G, ZHENG, BINHAI · 2003 to 2022
$9.0M
NEDD4 in right ventricular developmentR01HL158761 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI FANG, XI · 2021 to 2025
$2.5M
Molecular mechanisms and treatment of cardiomyopathy in Barth SyndromeR01HL157115 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI FANG, XI · 2021 to 2025
$2.0M
The role of GATAD1 in cardiomyocyte and cardiomyopathyR03TR004997 · NCATS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI FANG, XI · 2024 to 2024
$158k
AHA 24POST1196432NCATS NIH HHS R03 TR004997NHLBI NIH HHS R01 HL157115NHLBI NIH HHS R01 HL158761NIH HHS R03TR004997NINDS NIH HHS P30 NS047101
6 · The paper itself

Abstract

GATA zinc finger domain containing 1 (GATAD1) is an as-yet uncharacterized zinc finger domain protein, which was initially identified as a histone 3 trimethylated at lysine 4 (H3K4me3) interactor. A recessive mutation in GATAD1 is associated with adult-onset dilated cardiomyopathy and heart failure, suggesting that GATAD1 is critical for maintaining normal cardiac structure and function. However, little is known as to the specific role of GATAD1 in cardiomyocytes. A mammalian Gatad1 knockout model has yet to be generated for investigating its specific role in the heart. To address this, we generated a Gatad1 cardiomyocyte-specific knockout (cKO) mouse model. Gatad1 cKO mutants exhibited normal cardiac function during the aging process up to 18 months of age. Unlike the abnormal nuclei shape observed in patients carrying GATAD1 mutations, the nuclei shape of cardiomyocytes remained unaffected by the loss of Gatad1. Furthermore, Gatad1 cKO mice responded normally to pressure overload induced by transverse aortic constriction (TAC) surgery. Together, these observations suggest that deletion of Gatad1 in cardiomyocytes does not induce cardiomyopathy during aging or affect the response to pressure overload stress in mice.

Indexed as

CardiomyopathiesMice, KnockoutMyocytes, CardiacAnimalsDisease Models, AnimalMiceCardiomyopathyGatad1Genetic diseaseNuclear protein

Identifiers

PMID39641830
PMCPMC12054008

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.