Evidence map›Paper›PMID 39641814›Full record

ArticleMetabolic brain disease2024

Altered spontaneous brain activity in patients with progressive-stage and end-stage chronic kidney disease: insights from dALFF analysis.

Rujin Li, Mengchen Liu, Bin Xia, Ning Yang, Yanying Chen, Yi Yin, Kanghui Yu, Zichao Chen, Man Liang, Jiejing Li and 1 more

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Article in Metabolic brain disease, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

11 authors.

Rujin Li *The Second School of Clinical Medicine, Southern Medical University, Guangzhou, P. R. China.
Mengchen Liu *Department of Medical Imaging, The Affiliated Guangdong Second Provincial General Hospital of Jinan University, Shiliugang Rd, Haizhu District, Guangzhou, P. R. China.
Bin Xia *Department of Medical Imaging, The Affiliated Guangdong Second Provincial General Hospital of Jinan University, Shiliugang Rd, Haizhu District, Guangzhou, P. R. China.
Ning YangDepartment of Medical Imaging, The Affiliated Guangdong Second Provincial General Hospital of Jinan University, Shiliugang Rd, Haizhu District, Guangzhou, P. R. China.
Yanying ChenDepartment of Medical Imaging, The Affiliated Guangdong Second Provincial General Hospital of Jinan University, Shiliugang Rd, Haizhu District, Guangzhou, P. R. China.
Yi YinDepartment of Medical Imaging, The Affiliated Guangdong Second Provincial General Hospital of Jinan University, Shiliugang Rd, Haizhu District, Guangzhou, P. R. China.
Kanghui YuDepartment of Medical Imaging, The Affiliated Guangdong Second Provincial General Hospital of Jinan University, Shiliugang Rd, Haizhu District, Guangzhou, P. R. China.
Zichao ChenDepartment of Medical Imaging, The Affiliated Guangdong Second Provincial General Hospital of Jinan University, Shiliugang Rd, Haizhu District, Guangzhou, P. R. China.
Man LiangDepartment of Medical Imaging, The Affiliated Guangdong Second Provincial General Hospital of Jinan University, Shiliugang Rd, Haizhu District, Guangzhou, P. R. China.
Jiejing LiThe Second School of Clinical Medicine, Southern Medical University, Guangzhou, P. R. China.
Yunfan WuThe Second School of Clinical Medicine, Southern Medical University, Guangzhou, P. R. China. wuyf@gd2h.org.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chronic kidney disease (CKD) is a worldwide public health problem. Its association with cognitive impairment has attracted widespread attention in the world. However, the neuropathological mechanisms underlying kidney-brain interactions in CKD remain unclear. Using the dynamic amplitude of low-frequency fluctuations (dALFF) technique, 21 patients with progressive-stage CKD (CKD stages 3-4), 22 patients with end-stage CKD (CKD stage 5, ESKD), and 23 healthy volunteers (HCs) were enrolled to explore the brain regions with dALFF abnormalities in the progressive-stage and end-stage CKD. We used biased correlation analyses to explore the relationship between dALFF values and clinical indicators in patients with progressive-stage and end-stage CKD. Patients with both progressive-stage CKD (stages 3-4) and ESKD had abnormal dALFF values in the right parahippocampus, right inferior temporal gyrus, and left cuneus compared with HCs. In addition, abnormal dALFF were present in the left fusiform gyrus, insula and hippocampus in patients with progressive-stage CKD and in the left inferior temporal gyrus in patients with ESKD. Biased correlation analysis showed that dALFF values in the right parahippocampus, left fusiform gyrus and left insula were positively correlated with serum creatinine concentrations in patients with progressive-stage CKD and that dALFF values in the left inferior temporal gyrus were negatively correlated with MoCA scores in patients with ESKD. Our findings highlight the variability of neuroimaging changes between different stages of CKD and provide new insights and research directions for an in-depth exploration of the neuropathological mechanisms of renal-brain interactions.

Indexed as

BrainKidney Failure, ChronicRenal Insufficiency, ChronicAdultAgedDisease ProgressionFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedChronic kidney diseaseCognitive impairmentDynamic amplitude of low-frequency fluctuationsEnd-stage kidney diseaseProgression

Identifiers

PMID39641814

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.