Evidence map›Paper›PMID 39641808›Full record

ReviewPediatric nephrology (Berlin, Germany)2025

How dialysis frequency and duration impact uremic toxin and fluid removal: a pediatric perspective.

Pauline Van Wesemael, Sunny Eloot, Ann Raes, Rukshana Shroff, Evelien Snauwaert

Abstract readReview
PubMed Publisher
In one paragraph

Review in Pediatric nephrology (Berlin, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Kidney international reports · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Pauline Van WesemaelDepartment of Pediatric Nephrology, Ghent University Hospital, Ghent, Belgium. pauline.vanwesemael@UGent.Be.ORCID http://orcid.org/0000-0003-0083-434X
Sunny ElootDepartment of Nephrology, Ghent University Hospital, Ghent, Belgium.ORCID http://orcid.org/0000-0002-6984-1743
Ann RaesDepartment of Pediatric Nephrology, Ghent University Hospital, Ghent, Belgium.ORCID http://orcid.org/0000-0001-7809-2505
Rukshana ShroffDepartment of Pediatric Nephrology, UCL Great Ormond Street Hospital for Children and Institute of Child Health, London, UK.ORCID http://orcid.org/0000-0001-8501-1072
Evelien SnauwaertDepartment of Pediatric Nephrology, Ghent University Hospital, Ghent, Belgium.ORCID http://orcid.org/0000-0003-2660-7460

Funding

Agentschap voor Innovatie door Wetenschap en Technologie IWT-TBM 150195Universitair Ziekenhuis Gent Fonds voor Innovatie en Klinisch Onderzoek (FIKO) type III
6 · The paper itself

Abstract

Three-weekly 4-h hemodialysis/hemodiafiltration (HD/HDF) per week has become the "standard HD/HDF" regimen in children across the globe, although increasingly criticized, since crucial determinants such as residual kidney function and patient preferences are not considered. As a consequence, several children fail to achieve adequate dialysis while on a "standard HD/HDF." In these circumstances, an extended dialysis prescription such as short daily (2-3 h/session, 5-7 days a week) or nocturnal HD/HDF (6-9 h/session, 3-5 days a week), either at home or in a dialysis center, may be considered. The purpose of this educational review is to summarize the impact of dialysis duration and frequency on uremic toxin and fluid removal. Moreover, we aim to summarize the existing literature on HD/HDF strategies with extended dialysis duration and/or increased frequency (> 12 h dialysis time per week) in pediatrics. Dialysis duration and frequency plays a crucial role in uremic toxin removal, in particular for uremic toxins with retarded transport in patients, such as phosphate, β

Indexed as

HemodiafiltrationKidney Failure, ChronicRenal DialysisUremiaUremic ToxinsChildHumansTime FactorsUremic ToxinsChildDialysis durationExtended hemodialysisUltrafiltration rateUremic toxins

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.