Evidence map›Paper›PMID 39641763›Full record

ArticleThe Journal of experimental medicine2025

Antiviral immunity lassoed down by excess RNA.

Erika Valeri, Anna Kajaste-Rudnitski

Abstract read
In one paragraph

Article in The Journal of experimental medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Erika ValeriSan Raffaele Telethon Institute for Gene Therapy, IRCCS San Raffaele Scientific Institute , Milan, Italy.ORCID 0009-0008-4358-1403
Anna Kajaste-RudnitskiDepartment of Biology and Biotechnology, University of Pavia, Pavia, Italy.ORCID 0000-0003-1549-2426

Funding

European Research Council ERC-CoG 819815
6 · The paper itself

Abstract

Two complementary works by Chan et al. (https://doi.org/10.1084/jem.20231725), and Ru et al. (https://doi.org/10.1084/jem.20240010), identify defective RNA processing as the root cause of impaired antiviral immunity against SARS-CoV2 in the human brainstem. These studies provide molecular insight into virus-associated severe brainstem encephalitis through PKR inactivation.

Indexed as

COVID-19SARS-CoV-2AnimalsBrain StemeIF-2 KinaseHumansRNA, ViraleIF-2 KinaseRNA, Viral

Identifiers

PMID39641763
PMCPMC11622878

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.