Evidence map›Paper›PMID 39641544›Full record

ReviewExperimental dermatology2024

Advances in Microbiome-Based Therapeutics for Dermatological Disorders: Current Insights and Future Directions.

Tushar Madaan, Kyla Doan, Alexandra Hartman, Dominick Gherardini, Alec Ventrola, Yuhang Zhang, Nalinikanth Kotagiri

Abstract readReview
In one paragraph

Review in Experimental dermatology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Review
  2. Subtype-Specific Efficacy of TopicalAllergy, asthma & immunology research · 2026
    Article
  3. Article
  4. Review
  5. Article
  6. Review
  7. Review
  8. Selective Modulation ofClinical, cosmetic and investigational dermatology · 2026
    Review
  9. Review
  10. Review
  11. Review
  12. Article
  13. Skin Microbiome in Health and Disease: Mechanisms and Emerging Therapeutic Strategies.Clinical, cosmetic and investigational dermatology · 2025
    Review
  14. Beneficial perspective onFrontiers in immunology · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Tushar MadaanJames L. Winkle College of Pharmacy, University of Cincinnati, Cincinnati, Ohio, USA.
Kyla DoanJames L. Winkle College of Pharmacy, University of Cincinnati, Cincinnati, Ohio, USA.
Alexandra HartmanJames L. Winkle College of Pharmacy, University of Cincinnati, Cincinnati, Ohio, USA.ORCID https://orcid.org/0000-0003-3445-9664
Dominick GherardiniJames L. Winkle College of Pharmacy, University of Cincinnati, Cincinnati, Ohio, USA.
Alec VentrolaJames L. Winkle College of Pharmacy, University of Cincinnati, Cincinnati, Ohio, USA.
Yuhang ZhangJames L. Winkle College of Pharmacy, University of Cincinnati, Cincinnati, Ohio, USA.
Nalinikanth KotagiriJames L. Winkle College of Pharmacy, University of Cincinnati, Cincinnati, Ohio, USA.ORCID https://orcid.org/0000-0003-0066-4563

Funding

Siderophore based molecular imaging of pulmonary infectionsR01HL168588 · NHLBI · UNIVERSITY OF CINCINNATI · PI Nalinikanth Kotagiri · 2023 to 2026
$2.4M
Genetically-encoded molecular imaging of genome-edited immune cellsR01CA279962 · NCI · UNIVERSITY OF CINCINNATI · PI Nalinikanth Kotagiri · 2024 to 2026
$2.3M
Congressionally Directed Medical Research Programs CDMRP ME200246NCI NIH HHS R01 CA279962NHLBI NIH HHS R01 HL168588Office of Extramural Research, National Institutes of Health R01CA279962Office of Extramural Research, National Institutes of Health R01HL168588
6 · The paper itself

Abstract

The human skin hosts an estimated 1000 bacterial species that are essential for maintaining skin health. Extensive clinical and preclinical studies have established the significant role of the skin microbiome in dermatological disorders such as atopic dermatitis, psoriasis, diabetic foot ulcers, hidradenitis suppurativa and skin cancers. In these conditions, the skin microbiome is not only altered but, in some cases, implicated in disease pathophysiology. Microbiome-based therapies (MBTs) represent an emerging category of live biotherapeutic products with tremendous potential as a novel intervention platform for skin diseases. Beyond using established wild-type strains native to the skin, these therapies can be enhanced to express targeted therapeutic molecules, offering more tailored treatment approaches. This review explores the role of the skin microbiome in various common skin disorders, with a particular focus on the development and therapeutic potential of MBTs for treating these conditions.

Indexed as

MicrobiotaSkinSkin DiseasesDermatitis, AtopicDiabetic FootHidradenitis SuppurativaHumansProbioticsPsoriasisSkin Neoplasmsacne vulgarisatopic dermatitisdiabetic foot diseasehidradenitis suppurativamicrobiome‐based therapeuticspsoriasisskin cancerskin microbiome

Identifiers

PMID39641544
PMCPMC11663288

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.