ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2025
Childhood adversity and late-life cognitive and brain health in a diverse cohort.
Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Childhood adversities and the exposome in dementia risk and brain health.Current opinion in psychiatry · 2026Review
- The long-term association of childhood neighborhood quality on cognitive function in later life: the mediating role of domestic violence.BMC psychology · 2026Article
- Adverse childhood experiences, early menopause, cognition, and dementia in older adults in the United States.Communications health · 2026Article
- Sex Differences in the Associations Among Early Life Adversity, Inflammation, and Cognition.Biomolecules · 2025Review
- Childhood adversity and late-life cognitive and brain health in a diverse cohort.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- The Association Between Divorce and Late-life Brain Health in a Racially and Ethnically Diverse Cohort of Older Adults.Alzheimer disease and associated disordersObservational
- Incident traumatic experiences and poor financial well-being: A double hit for cognitive decline?Alzheimer's & dementia (Amsterdam, Netherlands)Article
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Authors and funding
13 authors.
Funding
Abstract
introductionChildhood adversity harms neurodevelopment. Literature on late-life brain health is limited, and findings on late-life cognition are mixed.
methodsPooling data from Kaiser Healthy Aging and Diverse Life Experiences (KHANDLE) and Study of Healthy Aging in African Americans (STAR) cohorts, we assessed the impact of childhood adversity (factor score from seven self-reported items) on (a) executive function and verbal memory decline using linear mixed effects models (n = 2447), (b) structural magnetic resonance imaging (MRI) using linear regression (n = 618), and (c) amyloid positron emission tomography (PET) using generalized linear models (n = 331), all adjusting for early-life demographic and socioeconomic confounders.
resultsChildhood adversity was not associated with cognition except for a slightly faster decline in verbal memory ( DISCUSSION: More research evaluating sources of resilience, heterogeneity, and bias is needed to explain inconsistent findings across studies. HIGHLIGHTS: We developed measurement models to capture childhood adversity in a diverse cohort. Childhood adversity was associated with a slightly faster verbal memory decline. We examined childhood adversity's effect on structural MRI and amyloid PET measures. Higher childhood adversity was associated with larger temporal lobe volumes.
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