Article in American journal of physiology. Gastrointestinal and liver physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
6 authors.
Sarah PenrodDivision of Pediatric Pulmonology, Allergy, and Sleep Medicine, Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, Indiana, United States.
Xiaofang TangDivision of Neonatology, Perinatal and Pulmonary Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, United States.
Changsuk MoonDivision of Pulmonology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, United States.
Jeffrey A WhitsettDivision of Neonatology, Perinatal and Pulmonary Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, United States.
Anjaparavanda P NarenDivision of Pulmonology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, United States.
Yunjie HuangDivision of Pediatric Pulmonology, Allergy, and Sleep Medicine, Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, Indiana, United States.ORCID 0000-0002-2151-9499
Funding
Tumor Microenvironment and Metastasis ProgramP30CA082709 · NCI · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI David W Clapp · 1999 to 2026
$59.3M
Quality Assurance and Quality Control Project Management: Improving Submissions and Study Conduct in the Human Subjects Research Prior Approval ProcessUL1TR002529 · NCATS · INDIANA UNIVERSITY INDIANAPOLIS · PI MOE, SHARON M, WIEHE, SARAH ELIZABETH · 2018 to 2022
$27.2M
Pilot and Feasibility ProgramP30DK117467 · NIDDK · CINCINNATI CHILDRENS HOSP MED CTR · PI Raouf S. Amin · 2018 to 2026
$11.4M
Editing Alveolar Progenitor Cells for Correction of Monogenic DiseaseU01HL134745 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI KOTTON, DARRELL N., MORRISEY, EDWARD E · 2016 to 2022
$8.3M
Inhibition of an apical cAMP transporter (MRP4) in the gut induces diarrheaR01DK080834 · NIDDK · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI Anjaparavanda P Naren · 2009 to 2026
$6.8M
LungMap Phase II - Building a multidimensional map of developing human lungU01HL148856 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI WHITSETT, JEFFREY A, XU, YAN · 2019 to 2023
$4.5M
Uterine signaling networks in the pathogenesis of pulmonary lymphangioleiomyomatosis (LAM)R01HL153045 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI XU, YAN, YU, JANE · 2020 to 2023
$3.1M
A mechanistic 3D AI-powered map of genetic chILDU01HL175383 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI Jichao Chen, Kathryn Ann Wikenheiser-Brokamp · 2024 to 2026
$2.4M
Cystic Fibrosis Foundation (CFF) HUANG20F5-CIHHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) P30DK117467HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) R01-DK080834HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) R01-HL148856NCATS NIH HHS UL1 TR002529NCI NIH HHS P30 CA082709NHLBI NIH HHS R01 HL153045NHLBI NIH HHS U01 HL134745NHLBI NIH HHS U01 HL148856NHLBI NIH HHS U01 HL175383NIDDK NIH HHS P30 DK117467NIDDK NIH HHS R01 DK080834
6 · The paper itself
Abstract
Membrane proteins, such as the cystic fibrosis transmembrane-conductance regulator (CFTR), play a crucial role in gastrointestinal functions and health. Endoplasmic reticulum (ER) membrane protein complex (EMC), a multi-subunit insertase, mediates the incorporation of membrane segments into lipid bilayers during protein synthesis. Whether EMC regulates membrane proteins' processing and function in intestinal epithelial cells remains unclear. To investigate the role of EMC in the intestinal epithelium, we generated mice in which EMC subunit 3 (EMC3) was deleted in intestinal epithelial cells (EMC3
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
EMC3 is critical for CFTR function and calcium mobilization in the mouse intestinal epithelium. · full record | OpenQuestion