ArticleHeliyon2024
Investigating mechanical properties for developing a human infant cranial bone surrogate in pediatric craniofacial surgery.
Article in Heliyon, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Beyond the surgeon's feedback on bone behavior in the operating room, there is a paucity of data present in the literature on the mechanical properties of pediatric calvarial bone. The present study tested the calvarial bone of four species (Adult Humans, Dog, Pig, and Monkey) to find the mechanical properties. Three types of tests were performed; flexural, compression, and torsion to mimic how bone is handled during the surgery and the results were further compared with the existing published data for human pediatric calvarium. Test results indicated a significant difference between the modulus (p = 0.006 for flexural, 0.0002 for compression, and 0.0075 for shear) and strength (p = 0.0005 for flexural, 0.0051 for compression, and p < 0.0001 for shear) amongst the tested groups. Compared with published data, the flexural properties of the 12-day-old pig were found to be closest to that of an 11-month-old human infant (E = 0.783 GPa). In contrast, the adult human was found to have a flexural modulus 3.9 times that of the pig, and specimen thickness of adult humans had a strong positive correlation (r = 0.77, p = 0.0237) with its flexural modulus, strengthening the disparity between infant and adult human skull bone material properties. Based on these results, neonatal piglet calvarium was selected as a model for 1-year-old human infants commonly presented for total cranial vault reconstruction. These results will help to inform the development and use of new technologies and techniques for bone graft manipulation in the laboratory and the operating room.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.