ArticleHeliyon2024
No causal relationship between ankylosing spondylitis and Parkinson's disease: Insights from Mendelian randomization studies.
Article in Heliyon, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Retrospective cohort and cross-sectional studies have indicated an association between ankylosing spondylitis (AS) and Parkinson's disease (PD). However, owing the multitude of limitations, a consistent conclusion has not been determined. Furthermore, whether a causal relationship exists between these two diseases remains unclear. Methods: We conducted a two-way Mendelian randomization (MR) analysis using genome-wide association study data. For patients with PD, we utilised data from the ieu-b-7 database, whereas for patients with AS, we employed the three databases with the largest sample sizes for a combined analysis. These databases included ebi-a-GCST005529, finn-b-M13 ANKYLOSPON, and finn-b-M13 ANKYLOSPON STRICT. Our primary method of analysis was inverse variance weighting (IVW), supplemented by four other effective methods, to comprehensively infer a potential causal relationship between AS and PD. Additionally, we conduct various sensitivity analyses to assess the robustness of our estimates. Results: Based on our IVW MR analysis, no significant causal relationship between AS and PD was observed (odds ratio [OR] = 1.01, 95 % confidence interval [CI] = 0.99-1.03, P = 0.26). Additionally, our reverse MR analysis found no evidence supporting a significant causal relationship between PD and AS (OR = 0.93, 95 % CI = 0.85-1.01, P = 0.068). These results were substantiated by comprehensive sensitivity analyses that indicated minimal bias in the causal estimates. Conclusion: In contrast to numerous existing clinical studies, this study failed to provide evidence supporting a significant impact of AS on PD risk, or vice versa. Further investigations regarding the potential causal mechanisms linking AS and PD are warranted.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.