Evidence map›Paper›PMID 39640769›Full record

ArticleHeliyon2024

Absence of platelet overactivation and thrombosis formation among patients with coronary atherosclerosis disease after vaccination against SARS-CoV-2.

Huajie Xu, Xin Zhao, Peng Zhang, Yunjie Zhang, Qi Zhou, Huibin Wu, Bing Fan, Si Zhang, Hongyi Wu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Heliyon, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Huajie XuDepartment of Infectious Disease, Zhongshan Hospital, Fudan University, Shanghai, China.
Xin ZhaoDepartment of Cardiology, Zhongshan Hospital, Fudan University, Shanghai Institute of Cardiovascular Diseases, Shanghai, National Clinical Research Center for Interventional Medicine, China.
Peng ZhangDepartment of Cardiology, Zhongshan Hospital, Fudan University, Shanghai Institute of Cardiovascular Diseases, Shanghai, National Clinical Research Center for Interventional Medicine, China.
Yunjie ZhangDepartment of Biostatistics, School of Public Health, Fudan University, Shanghai, China.
Qi ZhouDepartment of Clinical Medicine, Shanghai Medical College, Fudan University, Shanghai, 200032, China.
Huibin WuZhongshan Hospital, Fudan University, Shanghai, 200032, China.
Bing FanDepartment of Cardiology, Zhongshan Hospital, Fudan University, Shanghai Institute of Cardiovascular Diseases, Shanghai, National Clinical Research Center for Interventional Medicine, China.
Si ZhangNHC Key Laboratory of Glycoconjugate Research, Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Fudan University, Shanghai, China.
Hongyi WuDepartment of Cardiology, Zhongshan Hospital, Fudan University, Shanghai Institute of Cardiovascular Diseases, Shanghai, National Clinical Research Center for Interventional Medicine, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Association of Coronavirus disease 2019 vaccines with thrombosis has raised concerns among patients with coronary atherosclerosis disease (CAD). Objectives: After vaccination against SARS-CoV-2, to detect thrombosis formation in atherosclerosis ApoE Methods: Atherosclerotic ApoE Results: In atherosclerotic ApoE Conclusions: Inactivated SARS-CoV-2 vaccines did not potentiate thrombosis formation in atherosclerotic mice. Inactivated SARS-CoV-2 vaccines did not enhance platelet activation, or trigger the production of PF4 and antiphospholipid antibodies in patients with CAD. In light of the observed thrombotic risks associated with adenovirus-based COVID-19 vaccines, inactivated vaccines may offer a potentially safer option for individuals with CAD.

Indexed as

CADInactivated SARS-CoV-2 vaccinePlatelet activationProthrombotic antibodyThrombosis

Identifiers

PMID39640769
PMCPMC11619953

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.