Evidence map›Paper›PMID 39640589›Full record

ArticleiScience2024

Lipid-lowering drug and complement factor H genotyping-personalized treatment strategy for age-related macular degeneration.

Can Can Xue, Kelvin Y C Teo, Yih Chung Tham, Hengtong Li, Sahil Thakur, Charumathi Sabanayagam, Qiao Fan, David L Silver, Xiaomeng Wang, Chui Ming Gemmy Cheung and 4 more

Abstract read
In one paragraph

Article in iScience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. How do genetic polymorphisms influence the efficacy of age-related macular degeneration treatments? A systematic review and meta-analysis.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026
    Pooled it
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Can Can XueSingapore Eye Research Institute, Singapore National Eye Centre, Singapore 169856, Singapore.
Kelvin Y C TeoSingapore Eye Research Institute, Singapore National Eye Centre, Singapore 169856, Singapore.
Yih Chung ThamSingapore Eye Research Institute, Singapore National Eye Centre, Singapore 169856, Singapore.
Hengtong LiCentre for Innovation & Precision Eye Health, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119228, Singapore.
Sahil ThakurSingapore Eye Research Institute, Singapore National Eye Centre, Singapore 169856, Singapore.
Charumathi SabanayagamSingapore Eye Research Institute, Singapore National Eye Centre, Singapore 169856, Singapore.
Qiao FanOphthalmology & Visual Sciences Academic Clinical Program (Eye ACP), Duke-NUS Medical School, Singapore 169857, Singapore.
David L SilverSignature Research Program in Cardiovascular and Metabolic Disorders, Duke-NUS Medical School, Singapore 169857, Singapore.
Xiaomeng WangSingapore Eye Research Institute, Singapore National Eye Centre, Singapore 169856, Singapore.
Chui Ming Gemmy CheungSingapore Eye Research Institute, Singapore National Eye Centre, Singapore 169856, Singapore.
Tien Yin WongSingapore Eye Research Institute, Singapore National Eye Centre, Singapore 169856, Singapore.
Usha ChakravarthyQueen's University of Belfast, Belfast BT7 1NN, UK.
Ching-Yu ChengSingapore Eye Research Institute, Singapore National Eye Centre, Singapore 169856, Singapore.
Simon NusinoviciSingapore Eye Research Institute, Singapore National Eye Centre, Singapore 169856, Singapore.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We investigated whether the effect of lipid-lowering drugs (LLDs) on age-related macular degeneration (AMD) differs according to the main complement genetic variants in Singapore Epidemiology of Eye Diseases (SEED) (

Indexed as

Cardiovascular medicineHealth sciencesInternal medicineMedical specialtyMedicinePharmacology

Identifiers

PMID39640589
PMCPMC11618023

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.