Evidence map›Paper›PMID 39640576›Full record

ArticleiScience2024

Oropharyngeal resistome remains stable during COVID-19 therapy, while fecal resistome shifts toward a less diverse resistotype.

Elizaveta V Starikova, Yulia S Galeeva, Dmitry E Fedorov, Elena V Korneenko, Anna S Speranskaya, Oksana V Selezneva, Polina Y Zoruk, Ksenia M Klimina, Vladimir A Veselovsky, Maxim D Morozov and 20 more

Abstract read
In one paragraph

Article in iScience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

30 authors.

Elizaveta V StarikovaResearch Institute for Systems Biology and Medicine, Moscow 117246, Russian Federation.
Yulia S GaleevaResearch Institute for Systems Biology and Medicine, Moscow 117246, Russian Federation.
Dmitry E FedorovResearch Institute for Systems Biology and Medicine, Moscow 117246, Russian Federation.
Elena V KorneenkoResearch Institute for Systems Biology and Medicine, Moscow 117246, Russian Federation.
Anna S SperanskayaResearch Institute for Systems Biology and Medicine, Moscow 117246, Russian Federation.
Oksana V SeleznevaLopukhin Federal Research and Clinical Center of Physical-Chemical Medicine of Federal Medical Biological Agency, Moscow 119435, Russian Federation.
Polina Y ZorukLopukhin Federal Research and Clinical Center of Physical-Chemical Medicine of Federal Medical Biological Agency, Moscow 119435, Russian Federation.
Ksenia M KliminaLopukhin Federal Research and Clinical Center of Physical-Chemical Medicine of Federal Medical Biological Agency, Moscow 119435, Russian Federation.
Vladimir A VeselovskyLopukhin Federal Research and Clinical Center of Physical-Chemical Medicine of Federal Medical Biological Agency, Moscow 119435, Russian Federation.
Maxim D MorozovLopukhin Federal Research and Clinical Center of Physical-Chemical Medicine of Federal Medical Biological Agency, Moscow 119435, Russian Federation.
Daria I BoldyrevaLopukhin Federal Research and Clinical Center of Physical-Chemical Medicine of Federal Medical Biological Agency, Moscow 119435, Russian Federation.
Evgenii I OlekhnovichLopukhin Federal Research and Clinical Center of Physical-Chemical Medicine of Federal Medical Biological Agency, Moscow 119435, Russian Federation.
Alexander I ManolovResearch Institute for Systems Biology and Medicine, Moscow 117246, Russian Federation.
Alexander V PavlenkoResearch Institute for Systems Biology and Medicine, Moscow 117246, Russian Federation.
Ivan E KozlovResearch Institute for Systems Biology and Medicine, Moscow 117246, Russian Federation.
Oleg O YanushevichMoscow State University of Medicine and Dentistry, Moscow 127473, Russian Federation.
Natella I KrikheliMoscow State University of Medicine and Dentistry, Moscow 127473, Russian Federation.
Oleg V LevchenkoMoscow State University of Medicine and Dentistry, Moscow 127473, Russian Federation.
Dmitry N AndreevMoscow State University of Medicine and Dentistry, Moscow 127473, Russian Federation.
Filipp S SokolovMoscow State University of Medicine and Dentistry, Moscow 127473, Russian Federation.
Aleksey K FomenkoMoscow State University of Medicine and Dentistry, Moscow 127473, Russian Federation.
Mikhail K DevkotaMoscow State University of Medicine and Dentistry, Moscow 127473, Russian Federation.
Nikolai G AndreevMoscow State University of Medicine and Dentistry, Moscow 127473, Russian Federation.
Andrey V ZaborovskyMoscow State University of Medicine and Dentistry, Moscow 127473, Russian Federation.
Sergei V TsaregorodtsevMoscow State University of Medicine and Dentistry, Moscow 127473, Russian Federation.
Vladimir V EvdokimovMoscow State University of Medicine and Dentistry, Moscow 127473, Russian Federation.
Petr A BelyMoscow State University of Medicine and Dentistry, Moscow 127473, Russian Federation.
Igor V MaevMoscow State University of Medicine and Dentistry, Moscow 127473, Russian Federation.
Vadim M GovorunResearch Institute for Systems Biology and Medicine, Moscow 117246, Russian Federation.
Elena N IlinaResearch Institute for Systems Biology and Medicine, Moscow 117246, Russian Federation.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Antimicrobial resistance poses a serious threat to global public health. The COVID-19 pandemic underscored the need to monitor the dissemination of antimicrobial resistance genes and understand the mechanisms driving this process. In this study, we analyzed changes to the oropharyngeal and fecal resistomes of patients with COVID-19 undergoing therapy in a hospital setting. A targeted sequencing panel of 4,937 resistance genes was used to comprehensively characterize resistomes. Our results demonstrated that the oropharyngeal resistome is homogeneous, showing low variability over time. In contrast, fecal samples clustered into two distinct resistotypes that were only partially related to enterotypes. Approximately half of the patients changed their resistotype within a week of therapy, with the majority transitioning to a less diverse and

Indexed as

Clinical microbiologyEvolutionary mechanismsMicrobial geneticsMicrobiome

Identifiers

PMID39640576
PMCPMC11617248

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.