Evidence map›Paper›PMID 39640569›Full record

ArticleiScience2024

Tracking fructose 1,6-bisphosphate dynamics in liver cancer cells using a fluorescent biosensor.

Israel Pérez-Chávez, John N Koberstein, Julia Malo Pueyo, Eduardo H Gilglioni, Didier Vertommen, Nicolas Baeyens, Daria Ezeriņa, Esteban N Gurzov, Joris Messens

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Structural basis of G6P/Pi transport and inhibition in SLC37A4.Nature structural & molecular biology · 2026
    Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Israel Pérez-ChávezVIB-VUB Center for Structural Biology, Vlaams Instituut Voor Biotechnologie, B-1050 Brussels, Belgium.
John N KobersteinHHMI Janelia Research Campus, Ashburn, VA, USA.
Julia Malo PueyoVIB-VUB Center for Structural Biology, Vlaams Instituut Voor Biotechnologie, B-1050 Brussels, Belgium.
Eduardo H GilglioniSignal Transduction and Metabolism Laboratory, Université Libre de Bruxelles (ULB), Brussels, Belgium.
Didier Vertommende Duve Institute, MASSPROT Platform, UCLouvain, 1200 Brussels, Belgium.
Nicolas BaeyensLaboratoire de Physiologie et de Pharmacologie (LAPP), Université Libre de Bruxelles (ULB), Brussels, Belgium.
Daria EzeriņaVIB-VUB Center for Structural Biology, Vlaams Instituut Voor Biotechnologie, B-1050 Brussels, Belgium.
Esteban N GurzovSignal Transduction and Metabolism Laboratory, Université Libre de Bruxelles (ULB), Brussels, Belgium.
Joris MessensVIB-VUB Center for Structural Biology, Vlaams Instituut Voor Biotechnologie, B-1050 Brussels, Belgium.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

HYlight is a genetically encoded fluorescent biosensor that ratiometrically monitors fructose 1,6-bisphosphate (FBP), a key glycolytic metabolite. Given the role of glucose in liver cancer metabolism, we expressed HYlight in human liver cancer cells and primary mouse hepatocytes. Through

Indexed as

biochemistry methodscancermetabolomics

Identifiers

PMID39640569
PMCPMC11617404

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.