ArticleCureus2024
A Rare Case of Juvenile Systemic Sclerosis With Concurrent Disseminated Tuberculosis: Diagnostic and Therapeutic Challenges.
Article in Cureus, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
1 citing paper in PubMed.
- Pulmonary Tuberculosis Complicating Interstitial Lung Disease in Systemic Sclerosis: A Case Report from a High TB Burden Country.Case reports in pulmonology · 2025Article
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We present the case of a 13-year-old female diagnosed with juvenile systemic sclerosis, diffuse cutaneous subtype, along with active disseminated tuberculosis. This co-occurrence poses unique diagnostic and therapeutic challenges, particularly given the risk of tuberculosis exacerbation due to immunosuppressive therapy required for systemic sclerosis. The patient had signs/symptoms like progressive skin tightening and Raynaud's phenomenon; the diagnosis was confirmed by the presence of anti-Scl-70 antibodies. Concurrently, active disseminated tuberculosis was identified by a cartridge-based nucleic acid amplification test (CBNAAT) and supported by high-resolution computed tomography (HRCT) thorax and fine needle aspiration cytology (FNAC) of the submandibular lymph node. Treatment involved anti-tuberculosis therapy prior to initiating immunosuppression, ensuring a careful balance between managing autoimmunity and infection. The case emphasizes the importance of multidisciplinary collaboration and vigilant follow-up in managing complex autoimmune conditions coexisting with infectious diseases. Early diagnosis and an individualized approach were crucial to achieving clinical improvement in this adolescent pediatric patient.
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Registered trials
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