ArticleCureus2024
The Influence of Tobacco Smoking Intensity on Hemodynamic Parameters: A Functional Transcranial Doppler Study on Vascular Reserve in Chronic Smokers.
Article in Cureus, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTobacco smoking is an independent risk factor for stroke. In acute and chronic settings, it affects cerebral blood flow, mean systolic velocities, changes of velocities in response to metabolic challenges, pulsatility, and resistance indices in otherwise healthy smokers. The objective of the study was to determine the influence of smoking intensity on hemodynamic parameters in nonsmokers and smokers.
methodsThis prospective study enrolled 34 healthy volunteers, 19 smokers and 15 nonsmokers. Epidemiological data were taken from all patients, and exhaled carbon monoxide concentration was measured in smokers. To obtain hemodynamic parameters, we performed functional transcranial Doppler (fTCD) recordings on the posterior cerebral artery for six minutes, consisting of three cycles with closed and opened eyes. We investigated mean systolic velocities, neurovascular responses, and pulsatility indices.
resultsSmokers had significantly lower blood flow velocities than nonsmokers (28.36±5.87 and 30.19±6.41, respectively). Neurovascular response as a marker of vasodilatory potential was significantly lower in smokers (14.27%±0.08%) than in the nonsmoker group (17.33%±0.06%). Smokers with higher exhaled carbon monoxide concentrations had lower blood flow velocities than those with lower CO concentrations. Smokers had higher levels of pulsatility indices compared to nonsmokers.
conclusionThe vasodilatory mechanism of cerebral blood vessels is impaired in chronic, otherwise healthy smokers.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.