Evidence map›Paper›PMID 39640079›Full record

ArticleInternational journal of pharmaceutics: X2024

Olive mill wastewater: From by-product to smart antioxidant material.

Marco Ruggeri, Fabrizio De Luca, Amedeo Ungolo, Barbara Vigani, Alejandro J Paredes, Eleonora Russo, Maria Grazia Bottone, Eleonora Bianchi, Franca Ferrari, Silvia Rossi and 1 more

Abstract read
In one paragraph

Article in International journal of pharmaceutics: X, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Marco RuggeriDepartment of Drug Sciences, University of Pavia, 27100 Pavia, Italy.
Fabrizio De LucaDepartment of Biology and Biotechnology "L. Spallanzani", University of Pavia, 27100 Pavia, Italy.
Amedeo UngoloDepartment of Drug Sciences, University of Pavia, 27100 Pavia, Italy.
Barbara ViganiDepartment of Drug Sciences, University of Pavia, 27100 Pavia, Italy.
Alejandro J ParedesSchool of Pharmacy, Queen's University Belfast, Medical Biology Centre, Belfast, United Kingdom.
Eleonora RussoDepartment of Pharmacy, University of Genoa, 16132 Genoa, Italy.
Maria Grazia BottoneDepartment of Biology and Biotechnology "L. Spallanzani", University of Pavia, 27100 Pavia, Italy.
Eleonora BianchiDepartment of Drug Sciences, University of Pavia, 27100 Pavia, Italy.
Franca FerrariDepartment of Drug Sciences, University of Pavia, 27100 Pavia, Italy.
Silvia RossiDepartment of Drug Sciences, University of Pavia, 27100 Pavia, Italy.
Giuseppina SandriDepartment of Drug Sciences, University of Pavia, 27100 Pavia, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Olive mill wastewater (OMWW) is a byproduct of olive oil extraction that represents a critical environmental concern due to its potential adverse effects on ecosystems. Given these premises, spray-dried microparticles were designed and developed using maltodextrins as carriers to encapsulate OMWW bioactive compounds. The microparticles were manufactured using an easily scalable and sustainable spray-drying process. The resulting microparticles were smooth, spherical, and exhibited a mean particle size of about 18 μm. The systems demonstrated notable antioxidant properties with a DPPH radical scavenging activity higher than 60 %, due to the polyphenolic compounds of OMWW (about 24 g gallic acid equivalents per g of sample). In addition, the microparticles supported fibroblast and macrophage viability at concentrations up to 1 mg/mL. They also determined a 4-fold inflammation reduction in macrophages, improved collagen expression in fibroblasts, and modulated oxidative stress on aged fibroblasts. In conclusion, these microparticles could be considered as promising medical devices in wound healing, while offering a sustainable solution for valorizing OMWW.

Indexed as

Gene expressionOlive mill wastewaterOxidative stressWound healing

Identifiers

PMID39640079
PMCPMC11617292

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.