Evidence map›Paper›PMID 39640055›Full record

ArticleAsian journal of pharmaceutical sciences2024

A new nano approach to prevent tumor growth in the local treatment of glioblastoma: Temozolomide and rutin-loaded hybrid layered composite nanofiber.

Melis Ercelik, Cagla Tekin, Melisa Gurbuz, Yagmur Tuncbilekli, Hazal Yılmaz Dogan, Busra Mutlu, Pınar Eser, Gulcin Tezcan, Fatma Nur Parın, Kenan Yildirim and 10 more

Abstract read
In one paragraph

Article in Asian journal of pharmaceutical sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Melis ErcelikDepartment of Medical Biology, Faculty of Medicine, Bursa Uludag University, Bursa, Turkey.
Cagla TekinDepartment of Medical Biology, Faculty of Medicine, Bursa Uludag University, Bursa, Turkey.
Melisa GurbuzDepartment of Medical Biology, Faculty of Medicine, Bursa Uludag University, Bursa, Turkey.
Yagmur TuncbilekliDepartment of Neurosurgery, Faculty of Medicine, Bursa Uludag University, Bursa, Turkey.
Hazal Yılmaz DoganDepartment of Metallurgical and Materials Engineering, Bursa Technical University, Bursa, Turkey.
Busra MutluDepartment of Metallurgical and Materials Engineering, Bursa Technical University, Bursa, Turkey.
Pınar EserDepartment of Neurosurgery, Faculty of Medicine, Bursa Uludag University, Bursa, Turkey.
Gulcin TezcanDepartment of Fundamental Sciences, Faculty of Dentistry, Bursa Uludag University, Bursa, Turkey.
Fatma Nur ParınDepartment of Polymer Materials Engineering, Faculty of Engineering and Natural Sciences, Bursa Technical University, Bursa, Turkey.
Kenan YildirimDepartment of Polymer Materials Engineering, Faculty of Engineering and Natural Sciences, Bursa Technical University, Bursa, Turkey.
Mehmet SarihanDepartment of Medical Biology/Proteomics Laboratory, Kocaeli University, Kocaeli, Turkey.
Gurler AkpinarDepartment of Medical Biology/Proteomics Laboratory, Kocaeli University, Kocaeli, Turkey.
Murat KasapDepartment of Medical Biology/Proteomics Laboratory, Kocaeli University, Kocaeli, Turkey.
Ahmet BekarDepartment of Neurosurgery, Faculty of Medicine, Bursa Uludag University, Bursa, Turkey.
Hasan KocaeliDepartment of Neurosurgery, Faculty of Medicine, Bursa Uludag University, Bursa, Turkey.
Mevlut Ozgur TaskapiliogluDepartment of Neurosurgery, Faculty of Medicine, Istanbul Yeni Yuzyıl University, Istanbul, Turkey.
Secil Ak AksoyInegol Vocation School, Bursa Uludag University, Bursa, Turkey.
Rıfat OzparDepartment of Radiology, Faculty of Medicine, Bursa Uludağ University, Bursa, Turkey.
Bahattin HakyemezDepartment of Radiology, Faculty of Medicine, Bursa Uludağ University, Bursa, Turkey.
Berrin TuncaDepartment of Medical Biology, Faculty of Medicine, Bursa Uludag University, Bursa, Turkey.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Total resection of glioblastoma (GB) tumors is nearly impossible, and systemic administration of temozolomide (TMZ) is often inadequate. This study presents a hybrid layered composite nanofiber mesh (LHN) designed for localized treatment in GB tumor bed. The LHN, consisting of polyvinyl alcohol and core-shell polylactic acid layers, was loaded with TMZ and rutin.

Indexed as

GlioblastomaHybrid layered composite nanofiber webLocal treatmentRutinTemozolomide

Identifiers

PMID39640055
PMCPMC11617954

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.