ArticleFrontiers in psychology2024
Analysis of BoDV-1 status, EEG resting-state alpha activity and pro-inflammatory cytokines in adults with and without major depressive disorder.
Article in Frontiers in psychology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Lymphocyte subpopulations and EEG asymmetry.Journal of neural transmission (Vienna, Austria : 1996) · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: In severe cases, an infection with the Borna Disease Virus 1 (BoDV-1), the causative agent of Borna disease in horses, sheep, and other domestic mammals, was reported to be accompanied by cognitive dysfunctions, seizures, deep coma, or severe to fatal encephalitis in humans. In addition, asymptomatic or mild courses of BoDV-1 infection are discussed to act as a co-factor in the etiology of Major Depressive Disorder (MDD). Previously, studies using electroencephalography (EEG) reported BoDV-1-dependent changes in event-related potentials (ERPs), thus indicating the use and added value of non-invasive studies in Borna research. Methods: Here, we examined possible connections between BoDV-1 status, EEG restingstate alpha activity, and serum levels of pro-inflammatory Interleukin 6 (IL-6) and Interleukin 8 (IL-8) in MDD patients and in a comparison group of adults without MDD diagnosis. Results: Interestingly, for both groups, we revealed a comparable high number of BoDV-1 positive and BoDV-1 negative participants. Compared to adults without MDD diagnosis, MDD patients showed a decrease in their relative EEG alpha power at posterio-central, but increased values at anterio-central electrode sites. Most important, no group-dependent effect of BoDV-1 status on EEG resting-state activity had been observed. Compared to BoDV-1 positive and negative adults without MDD diagnosis, as well as BoDV-1 positive MDD patients, BoDV-1 negative MDD patients revealed a comparatively weak significant negative correlation between relative fronto-central EEG alpha power and concentrations of pro-inflammatory IL-8. Discussion: Taken together, our data confirm MDD-dependent alterations in EEG resting-state alpha activity, which, however, were not accompanied by major BoDV-1 dependent neurophysiological or immunological effects. Future - probably more invasive - studies further have to clarify the significance of the observed negative correlation between relative fronto-central EEG alpha power and concentrations of pro-inflammatory IL-8.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.