Evidence map›Paper›PMID 39640027›Full record

ReviewChemical science2025

Magic methylation with methyl-containing peroxides.

Daliah Farajat, Yuhua Zhang, Chao-Jun Li

Abstract readReview
In one paragraph

Review in Chemical science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Daliah FarajatDepartment of Chemistry, McGill University 801 Sherbrooke Street West Montreal Quebec H3A 2K6 Canada cj.li@mcgill.ca.ORCID https://orcid.org/0009-0005-1231-8440
Yuhua ZhangAccustandard Inc. 125 Market Street New Haven Connecticut 06513 USA.
Chao-Jun LiDepartment of Chemistry, McGill University 801 Sherbrooke Street West Montreal Quebec H3A 2K6 Canada cj.li@mcgill.ca.ORCID https://orcid.org/0000-0002-3859-8824

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Methyl groups rank among the most abundant carbon fragments found in natural products and small-molecule pharmaceuticals. The late-stage and environmentally friendly installation of these groups onto biologically active molecules has attracted widespread attention in both industry and academia. In 2008, we published the first use of a methyl radical derived from a peroxide toward a directed transition-metal catalysed C-H methylation. In the past sixteen years, methyl-containing peroxides have proven themselves as robust reagents for introducing methyl groups onto organic molecules. In this review, our goal is to provide a thorough summary of the research advancements achieved in this field thus far.

Identifiers

PMID39640027
PMCPMC11615666

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.