Evidence map›Paper›PMID 39639997›Full record

ArticleVessel plus2023

The biomechanics and prevention of vein graft failure in coronary revascularization.

Elbert E Heng, Hanjay Wang, Oluwatomisin Obafemi, Alison Marsden, Y Joseph Woo, Jack H Boyd

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Vessel plus, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. A computational framework to optimize the mechanical behavior of synthetic vascular grafts.Journal of the mechanical behavior of biomedical materials · 2025
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Elbert E HengDepartment of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA.
Hanjay WangDepartment of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA.
Oluwatomisin ObafemiDepartment of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA.
Alison MarsdenStanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA 94305, USA.
Y Joseph WooDepartment of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA.
Jack H BoydDepartment of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA.

Funding

ANGIOGENIC TISSUE ENGINEERING TO LIMIT POST-INFARCTION VENTRICULAR REMODELINGR01HL089315 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI WOO, Y JOSEPH · 2008 to 2023
$6.4M
Computational model-driven design to mitigate vein graft failure after coronary artery bypassR01HL159954 · NHLBI · STANFORD UNIVERSITY · PI HUMPHREY, JAY D., MARSDEN, ALISON L · 2022 to 2025
$2.7M
Multiscale modeling for vein graft failure risk stratification in CABG patientsR01HL123689 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MARSDEN, ALISON L · 2014 to 2018
$1.9M
NHLBI NIH HHS R01 HL089315NHLBI NIH HHS R01 HL123689NHLBI NIH HHS R01 HL159954
6 · The paper itself

Abstract

Saphenous vein grafts (SVGs) are the most widely used conduit in coronary artery bypass grafting (CABG) surgery; however, SVG failures due to neointimal hyperplasia present a significant long-term limitation to the effectiveness of myocardial revascularization. This review will provide a comprehensive overview of the biological mechanisms of vein graft failure, including compensatory endothelial proliferation, extracellular matrix deposition, and adventitial disruption. We will discuss historical and emerging strategies for vein graft failure prevention with a focus on the role of mechanical vein graft support using external stenting. Finally, we will highlight the results of preclinical and human trials and discuss future directions for investigation.

Indexed as

Coronary artery bypass graftingexternal stentingneointimal hyperplasiasaphenous veinvein graft failurevein graft remodeling

Identifiers

PMID39639997
PMCPMC11620001

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.