Evidence map›Paper›PMID 39639850›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025

A Body-Temperature-Triggered In Situ Softening Peripheral Nerve Electrode for Chronic Robust Neuromodulation.

Xueyang Ren, Wenjie Tang, Yuehui Yuan, Shisheng Chen, Fangzhou Lu, Jinyang Mao, Jidan Fan, Xufeng Wei, Ming Chu, Benhui Hu

Abstract read
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Xueyang RenSchool of Biomedical Engineering and Informatics, Nanjing Medical University, Nanjing, 211166, China.ORCID https://orcid.org/0000-0002-7629-9948
Wenjie TangSchool of Biomedical Engineering and Informatics, Nanjing Medical University, Nanjing, 211166, China.
Yuehui YuanSchool of Biomedical Engineering and Informatics, Nanjing Medical University, Nanjing, 211166, China.
Shisheng ChenSchool of Biomedical Engineering and Informatics, Nanjing Medical University, Nanjing, 211166, China.
Fangzhou LuDepartment of Endocrinology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China.
Jinyang MaoThe Affiliated Taizhou People's Hospital of Nanjing Medical University, Taizhou School of Clinical Medicine, Nanjing Medical University, Taizhou, 225300, China.
Jidan FanThe Affiliated Taizhou People's Hospital of Nanjing Medical University, Taizhou School of Clinical Medicine, Nanjing Medical University, Taizhou, 225300, China.
Xufeng WeiThe Affiliated Taizhou People's Hospital of Nanjing Medical University, Taizhou School of Clinical Medicine, Nanjing Medical University, Taizhou, 225300, China.
Ming ChuThe Affiliated Taizhou People's Hospital of Nanjing Medical University, Taizhou School of Clinical Medicine, Nanjing Medical University, Taizhou, 225300, China.
Benhui HuSchool of Biomedical Engineering and Informatics, Nanjing Medical University, Nanjing, 211166, China.ORCID https://orcid.org/0000-0002-7404-6525

Funding

Key Program of Taizhou School of Clinical Medicine, Nanjing Medical University TZKY20220305Nanjing Medical University Cultivation Fund 2024NJMUQA10Nanjing Medical University Cultivation Fund NJMUGSPB202404Nanjing Medical University Cultivation Fund SKLRM-2024A5Natural Science Foundation of Jiangsu Province BK20240029
6 · The paper itself

Abstract

Implantable peripheral nerve electrodes are crucial for monitoring health and alleviating symptoms of chronic diseases. Advanced compliant electrodes have been developed because of their biomechanical compatibility. However, these mechanically tissue-like electrodes suffer from unmanageable operating forces, leading to high risks of nerve injury and fragile electrode-tissue interfaces. Here, a peripheral nerve electrode is developed that simultaneously fulfills the criteria of body temperature softening and tissue-like modulus (less than 0.8 MPa at 37 °C) after implantation. The central core is altered from the tri-arm crosslinker to the star-branched monomer to kill two birds (close the translation temperature to 37 °C and decrease the modulus after implantation) with one stone. Furthermore, the decreased interfacial impedance (325.1 ± 46.9 Ω at 1 kHz) and increased charge storage capacity (111.2 ± 5.8 mC cm

Indexed as

Body TemperatureElectrodes, ImplantedPeripheral NervesAnimalsRatsin situ softeningmyocardial remodelingneuromodulationperipheral nerve electrodes

Identifiers

PMID39639850
PMCPMC11791928

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.