Evidence map›Paper›PMID 39639357›Full record

ArticleParticle and fibre toxicology2024

Acute airway inflammation following controlled biodiesel exhaust exposure in healthy subjects.

Thomas Sandström, Jenny A Bosson, Ala Muala, Mikael Kabéle, Jamshid Pourazar, Christoffer Boman, Gregory Rankin, Ian S Mudway, Anders Blomberg, Maria Friberg

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Particle and fibre toxicology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Thomas Sandström *Department of Public Health and Clinical Medicine, Umeå University, SE-901 87, Umeå, Sweden.
Jenny A Bosson *Department of Public Health and Clinical Medicine, Umeå University, SE-901 87, Umeå, Sweden.
Ala MualaDepartment of Public Health and Clinical Medicine, Umeå University, SE-901 87, Umeå, Sweden.
Mikael KabéleDepartment of Public Health and Clinical Medicine, Umeå University, SE-901 87, Umeå, Sweden.
Jamshid PourazarDepartment of Public Health and Clinical Medicine, Umeå University, SE-901 87, Umeå, Sweden.
Christoffer BomanThermochemical Energy Conversion Laboratory, Department of Applied Physics and Electronics, Umeå University, Umeå, Sweden.
Gregory RankinDepartment of Public Health and Clinical Medicine, Umeå University, SE-901 87, Umeå, Sweden.
Ian S MudwayNIHR Health Protection Research Unit in Environmental Exposures and Health, MRC-PHE Centre for Environment and Health, Imperial College London, London, UK.
Anders BlombergDepartment of Public Health and Clinical Medicine, Umeå University, SE-901 87, Umeå, Sweden.
Maria FribergDepartment of Public Health and Clinical Medicine, Umeå University, SE-901 87, Umeå, Sweden. maria.friberg@umu.se.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundExposure to standard petrodiesel exhaust is linked to adverse health effects. Moreover, there is a mounting request to replace fossil-based fuels with renewable and sustainable alternatives and, therefore, rapeseed methyl ester (RME) and other biofuels have been introduced. However, recent toxicological research has indicated that biodiesel exhaust may also induce adverse health-related events.

aimTo determine whether exposure to 100% RME biodiesel (BD100) exhaust would cause an acute airway neutrophilic recruitment in humans.

methodsFourteen healthy subjects underwent exposure to diluted BD100 exhaust and filtered air for 1-h, in a blinded, random fashion. Bronchoscopy with endobronchial mucosal biopsies, bronchial wash (BW) and bronchoalveolar lavage (BAL) was performed six hours after exposure. Differential cell counts and inflammatory markers were determined in the supernatant and biopsies were stained immunohistochemically.

resultsCompared with filtered air, BD100 exhaust exposure increased bronchial mucosal endothelial P-selectin adhesion molecule expression, as well as neutrophil, mast cell and CD68 + macrophage numbers. An increased influx of neutrophils and machrophages was also seen in BW.

conclusionExposure to biodiesel exhaust was associated with an acute airway inflammation that appeared similar to preceding petrodiesel exposure studies. The present findings, together with the recently reported adverse cardiovascular effects after similar biodiesel exposure, indicate that biodiesel is not free of toxicity and may affect human health.

Indexed as

BiofuelsInhalation ExposureVehicle EmissionsAdultAir PollutantsAntigens, CDAntigens, Differentiation, MyelomonocyticBronchiBronchoalveolar Lavage FluidBronchoscopyCD68 MoleculeFemaleHealthy VolunteersHumansMacrophagesMaleAir PollutantsAntigens, CDAntigens, Differentiation, MyelomonocyticBiofuelsCD68 antigen, humanCD68 MoleculeVehicle EmissionsAir pollutionBiodieselBronchial biopsyBronchoscopyChamber exposureLungRenewable fuel

Identifiers

PMID39639357
PMCPMC11619701

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.