Evidence map›Paper›PMID 39639333›Full record

ArticleMicrobiome2024

Analysis of early childhood intestinal microbial dynamics in a continuous-flow bioreactor.

Alessandra Granato, Simone Renwick, Christopher Yau, Tiffany Kong, Michelle C Daigneault, Mikael Knip, DIABIMMUNE Study Group, Emma Allen-Vercoe, Jayne S Danska

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Microbiome, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Alessandra Granato *Genetics and Genome Biology, The Hospital for Sick Children, Toronto, ON, Canada.
Simone Renwick *Dept. of Molecular and Cellular Biology, University of Guelph, Guelph, ON, Canada.
Christopher Yau *Genetics and Genome Biology, The Hospital for Sick Children, Toronto, ON, Canada.
Tiffany Kong *Genetics and Genome Biology, The Hospital for Sick Children, Toronto, ON, Canada.
Michelle C DaigneaultDept. of Molecular and Cellular Biology, University of Guelph, Guelph, ON, Canada.
Mikael KnipResearch Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
DIABIMMUNE Study Group
Emma Allen-VercoeDept. of Molecular and Cellular Biology, University of Guelph, Guelph, ON, Canada.
Jayne S DanskaGenetics and Genome Biology, The Hospital for Sick Children, Toronto, ON, Canada. jayne.danska@sickkids.ca.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe human gut microbiota is inoculated at birth and undergoes a process of assembly and diversification during the first few years of life. Studies in mice and humans have revealed associations between the early-life gut microbiome and future susceptibility to immune and metabolic diseases. To resolve microbe and host contributing factors to early-life development and to disease states requires experimental platforms that support reproducible, longitudinal, and high-content analyses.

resultsHere, we deployed a continuous single-stage chemostat culture model of the human distal gut to study gut microbiota from 18- to 24-month-old children integrating both culture-dependent and -independent methods. Chemostat cultures recapitulated multiple aspects of the fecal microbial ecosystem enabling investigation of relationships between bacterial strains and metabolic function, as well as a resource from which we isolated and curated a diverse library of early life bacterial strains.

conclusionsWe report the reproducible, longitudinal dynamics of early-life bacterial communities cultured in an advanced model of the human gut providing an experimental approach and a characterized bacterial resource to support future investigations of the human gut microbiota in early childhood.

Indexed as

BacteriaBioreactorsFecesGastrointestinal MicrobiomeChild, PreschoolFemaleHumansInfantMaleRNA, Ribosomal, 16SRNA, Ribosomal, 16SAnexic isolationBacterial metabolitesChemostat continuous cultureDefined bacterial consortiaEarly childhood microbiome

Identifiers

PMID39639333
PMCPMC11619690

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.