Evidence map›Paper›PMID 39639324›Full record

ArticleCritical care (London, England)2024

Longitudinal assessment of immunoglobulin response and disease progression in critically ill patients with community acquired pneumonia.

Emma Rademaker, Lisette M Vernooij, Tom van der Poll, Marc J M Bonten, Helen Leavis, Olaf L Cremer, Lennie P G Derde

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Critical care (London, England), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Emma RademakerJulius Center for Health Sciences and Primary Care, Heidelberglaan 100, 3584 CX, Utrecht, The Netherlands. e.rademaker-2@umcutrecht.nl.ORCID 0000-0001-5143-5723
Lisette M VernooijDepartment of Intensive Care, UMC Utrecht, Utrecht, The Netherlands.
Tom van der PollCenter for Experimental and Molecular Medicine and Division of Infectious Diseases, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
Marc J M BontenJulius Center for Health Sciences and Primary Care, Heidelberglaan 100, 3584 CX, Utrecht, The Netherlands.
Helen LeavisDepartment of Rheumatology and Clinical Immunology, UMC Utrecht, Utrecht, The Netherlands.
Olaf L CremerDepartment of Intensive Care, UMC Utrecht, Utrecht, The Netherlands.
Lennie P G DerdeJulius Center for Health Sciences and Primary Care, Heidelberglaan 100, 3584 CX, Utrecht, The Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundLow endogenous immunoglobulin(Ig)-levels are common in critically ill patients with sepsis, but it is unknown whether low Ig-levels are associated with poor outcome, and in which patients Ig-replacement therapy (IgRT) improves outcome. Given the crucial role of immunoglobulins in eliminating certain encapsulated pathogens, we examined the relationship between serial Ig-levels and disease course in critically ill patients with community acquired pneumonia (sCAP) caused by encapsulated or other pathogens.

methodsWe included a cohort of consecutive critically ill patients with CAP, and PaO

resultsWe included 255 eligible patients admitted with CAP, of which 82 (32%) episodes were caused by S. pneumoniae or H. influenzae. 151 (59%) patients had low IgG (< 7.0 g/L), 77 (30%) had low IgM (< 0.4 g/L), and 56 (22%) had both. A lower IgG-level was related to a slightly higher SOFA-score at admission (β =  - 0.07 per 1 g/L IgG, p = 0.029), but an IgG-level decline over time was not associated with a SOFA-score increase (β =  - 0.04, p = 0.564). IgM-levels were not associated with changes in SOFA-score over time. Neither association was affected by the presence or absence of S. pneumoniae and H. influenzae.

conclusionIn critically ill patients with CAP, IgG and IgM dynamics in the first week of ICU stay are not associated with clinically relevant changes in disease course, regardless of the causative pathogen.

Indexed as

Community-Acquired InfectionsCritical IllnessDisease ProgressionAgedCohort StudiesFemaleHumansImmunoglobulin GImmunoglobulin MImmunoglobulinsLongitudinal StudiesMaleMiddle AgedOrgan Dysfunction ScoresPneumoniaImmunoglobulin GImmunoglobulin MImmunoglobulinsCritical illnessHypogammaglobulinemiaIntravenous immunoglobulinsPersonalized medicinePneumonia

Identifiers

PMID39639324
PMCPMC11622494

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.