ArticleJournal of perinatology : official journal of the California Perinatal Association2025
Acute kidney injury associated with increased costs in the neonatal intensive care unit: analysis of Pediatric Health Information System database.
Article in Journal of perinatology : official journal of the California Perinatal Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Time to diagnosis of acute kidney injury and its predictors among outborn neonates in India: a competing-risk analysis of tele-ICU network data (2022-2024).The Lancet regional health. Southeast Asia · 2026Article
- A Pathophysiological Approach for Early Detection and Prevention of AKI in the NICU.American journal of perinatology · 2026Review
- Incidence, Predictors, and Outcomes Associated with Recurrent Neonatal Acute Kidney Injury in Preterm Infants: A Secondary Analysis of the Preterm Erythropoietin Neuroprotection Trial (PENUT).Research square · 2026Article
- Neonatal Acute Kidney Injury-An Australian and New Zealand Perspective.Journal of paediatrics and child health · 2026Review
- Perinatal risk factors and 2-year neurodevelopmental outcome of early acute kidney injury in very preterm and very low birth weight infants.Pediatric nephrology (Berlin, Germany) · 2026Article
- Using health systems evidence to study and predict long-term outcomes of childhood acute kidney injury.Pediatric nephrology (Berlin, Germany) · 2026Article
- Understanding the Impact of Patent Ductus Arteriosus and Treatment Strategies on Acute Kidney Injury in Preterm Infants.American journal of perinatology · 2026Review
- Efficacy of the STARZ stratification score in determining the risk of acute kidney injury in critically ill neonates.Pediatric nephrology (Berlin, Germany) · 2026Article
- Global economic burden of neonatal acute kidney injury (AKI): the hidden costs of medical elopement.Journal of perinatology : official journal of the California Perinatal Association · 2026Article
- Advances in pediatric acute kidney injury detection and prediction: biomarkers and artificial intelligence.World journal of pediatrics : WJP · 2025Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
objectiveCompare neonatal intensive care unit hospitalization costs between neonates with and without AKI; identify predictors of AKI-associated costs. We hypothesized neonates with AKI would amass more costs than those without AKI. STUDY
designRetrospective, multicenter cohort study of surviving neonates cared for 2015-2021 in Pediatric Health Information System database. The primary outcome was estimated hospitalization costs.
resultsData from 304,725 neonates were evaluated, 8774 (3%) with AKI and 295,951 (97%) without AKI. Neonates with AKI had $58,807 greater adjusted costs than those without AKI. AKI-associated costs were most strongly driven by Feudtner Pediatric Complex Chronic Conditions Classifications (cardiovascaular, congenital/genetic, gastrointestinal, medical technology) and gestational age. Adjusted costs decreased with increasing gestational age, regardless of AKI status.
conclusionsAKI is independently associated with increased hospital costs. Knowledge of these drivers can help in identifying high-value practices for cost mitigation strategies.
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