Evidence map›Paper›PMID 39639119›Full record

ArticleScientific reports2024

Enhancement of chlorpromazine efficacy in breast cancer treatment by 266 nm laser irradiation.

Ana Maria Udrea, Angela Staicu, Adriana Smarandache, Ionut Relu Andrei, Madalina Andreea Badea, Speranta Avram, Mihail Lucian Pascu, Ruxandra Angela Pirvulescu, Mihaela Balas

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ana Maria UdreaNational Institute for Laser, Plasma and Radiation Physics (INFLPR), 409 Atomistilor Street, Magurele, 077125, Romania.
Angela StaicuNational Institute for Laser, Plasma and Radiation Physics (INFLPR), 409 Atomistilor Street, Magurele, 077125, Romania. angela.staicu@inflpr.ro.
Adriana SmarandacheNational Institute for Laser, Plasma and Radiation Physics (INFLPR), 409 Atomistilor Street, Magurele, 077125, Romania.
Ionut Relu AndreiNational Institute for Laser, Plasma and Radiation Physics (INFLPR), 409 Atomistilor Street, Magurele, 077125, Romania.
Madalina Andreea BadeaDepartment of Biochemistry and Molecular Biology, Faculty of Biology, University of Bucharest, 91-95 Splaiul Independentei, Bucharest, 050095, Romania.
Speranta AvramDepartment of Anatomy, Animal Physiology and Biophysics, Faculty of Biology, University of Bucharest, 91-95 Splaiul Independentei, Bucharest, 050095, Romania.
Mihail Lucian PascuNational Institute for Laser, Plasma and Radiation Physics (INFLPR), 409 Atomistilor Street, Magurele, 077125, Romania.
Ruxandra Angela PirvulescuCarol Davila University of Medicine and Pharmacy, 37 Dionisie Lupu Street, Bucharest, 020021, Romania.
Mihaela BalasDepartment of Biochemistry and Molecular Biology, Faculty of Biology, University of Bucharest, 91-95 Splaiul Independentei, Bucharest, 050095, Romania. mihaela.balas@bio.unibuc.ro.

Funding

Unitatea Executiva pentru Finantarea Invatamantului Superior, a Cercetarii, Dezvoltarii si Inovarii PN-III-P1-1.1-PD-2021-0225
6 · The paper itself

Abstract

Breast cancer remains a global health challenge, prompting interest in the anticancer properties of other drugs, including chlorpromazine (CPZ). This study presents a novel approach in breast cancer treatment using laser irradiated CPZ. CPZ dissolved in distilled water, was exposed to 266 nm laser irradiation for varying durations, characterized by UV-Vis and FTIR spectroscopy, followed by drug-likeness and ADME-Tox predictions. In vitro assays evaluated the cytotoxicity and cellular effects on MCF-7 breast cancer cells, and compared with MCF-12 A healthy cell line. Laser irradiation altered CPZ molecular structure resulting in photoproducts with favourable drug-like properties and ADME-Tox profiles. In vitro evaluations demonstrate dose and irradiation time-dependent cytotoxicity against breast cancer cells, and reduced toxicity on healthy cell line. Significant alterations in F-actin organization, and excessive ROS generation were also proved, suggesting the potential of laser-modified CPZ for breast cancer therapy. This study introduces a novel approach to breast cancer treatment through laser irradiated CPZ, highlighting promising advancements in therapy and emphasizing the role of laser-generated compounds.

Indexed as

Breast NeoplasmsChlorpromazineAntineoplastic AgentsCell Line, TumorCell SurvivalFemaleHumansLasersMCF-7 CellsReactive Oxygen SpeciesAntineoplastic AgentsChlorpromazineReactive Oxygen SpeciesADME-ToxAntipsychotic drugsBreast cancerChlorpromazineDrug repositioningLaser-irradiated drugs

Identifiers

PMID39639119
PMCPMC11621703

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.