Trial reportPediatric research2025
Effects of infant feeding type on auditory event-related potentials at 24 months of age.
Trial report in Pediatric research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Milk fat globule membrane in early-life nutrition: composition, production, and biological effects on infant immune maturation, intestinal development, neurocognitive function, and growth.Frontiers in nutrition · 2026Review
- Human milk phospholipids across lactation stages and their associations with infant neurodevelopment: a prospective cohort study in China.Frontiers in nutrition · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAdded bovine milk fat globule membrane (bMFGM) or bMFGM components in infant formulas may favor language development essential for cognitive maturation in early life. In this study, the influence of infant feeding type on language skills acquisition was investigated.
methodsAuditory event-related potentials (ERPs) were performed at ~4-6 (baseline) and 24 months of age in infants receiving: human milk, as a reference group (HM, n = 42) or randomized to standard infant formula (SF, n = 53) or similar formula with added bMFGM (EF, n = 48) through 12 months of age. Auditive stimuli included three syllables (two native, one nonnative) with frequent or infrequent repetition. The main outcome was P1 wave amplitude and latency.
resultsAt baseline no significant differences were detected in P1 amplitude and latency by feeding or feeding×stimuli. At 24 months, P1 amplitude significantly differed by feeding type (P = 0.02; EF lowest). P1 latency for feeding×stimuli significantly differed for infrequent native (P = 0.01; longer for SF vs EF, P = 0.007).
conclusionElectrophysiological changes in ERPs at 24 months of age demonstrated differences by infant feeding type and suggested beneficial effects of formula with added bMFGM on connectivity involved in language perception development. IMPACT: First study to evaluate the nutritive effects of bovine milk fat globule membrane (bMFGM) on auditory event-related potentials (ERPs). First demonstration of differential language development associated with infant feeding type and bMFGM using an age-appropriate, high-sensitivity, electrophysiological method. Electrophysiological changes detected in ERPs at 24 months of age suggested an effect of added bMFGM in infant formula (compared to standard formula) which promotes faster neuronal transmission.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.