Evidence map›Paper›PMID 39639087›Full record

ArticleScientific reports2024

Effects of different ventilatory settings on alveolar and pulmonary microvessel dimensions in pigs.

Elisa Damiani, Erika Casarotta, Caterina Di Bella, Margherita Galosi, Alessio Angorini, Federica Serino, Adolfo Maria Tambella, Fulvio Laus, Samuele Zuccari, Alessio Salvucci Salice and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Elisa DamianiDepartment of Biomedical Sciences and Public Health, Università Politecnica delle Marche, via Trontro 10/a, 60126, Ancona, Italy. elisa.damiani@univpm.it.
Erika CasarottaDepartment of Biomedical Sciences and Public Health, Università Politecnica delle Marche, via Trontro 10/a, 60126, Ancona, Italy.
Caterina Di BellaSchool of Biosciences and Veterinary Medicine, University of Camerino, Camerino, Italy.
Margherita GalosiSchool of Biosciences and Veterinary Medicine, University of Camerino, Camerino, Italy.
Alessio AngoriniSchool of Biosciences and Veterinary Medicine, University of Camerino, Camerino, Italy.
Federica SerinoSchool of Biosciences and Veterinary Medicine, University of Camerino, Camerino, Italy.
Adolfo Maria TambellaSchool of Biosciences and Veterinary Medicine, University of Camerino, Camerino, Italy.
Fulvio LausSchool of Biosciences and Veterinary Medicine, University of Camerino, Camerino, Italy.
Samuele ZuccariAnesthesia and Intensive Care Unit, Azienda Ospedaliero Universitaria delle Marche, Ancona, Italy.
Alessio Salvucci SaliceDepartment of Biomedical Sciences and Public Health, Università Politecnica delle Marche, via Trontro 10/a, 60126, Ancona, Italy.
Roberta DomiziDepartment of Biomedical Sciences and Public Health, Università Politecnica delle Marche, via Trontro 10/a, 60126, Ancona, Italy.
Andrea CarsettiDepartment of Biomedical Sciences and Public Health, Università Politecnica delle Marche, via Trontro 10/a, 60126, Ancona, Italy.
Can InceDepartment of Intensive Care, Erasmus MC, University Medical Center, Rotterdam, The Netherlands.
Abele DonatiDepartment of Biomedical Sciences and Public Health, Università Politecnica delle Marche, via Trontro 10/a, 60126, Ancona, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mechanical ventilation with high tidal volume (TV) or positive end-expiratory pressure (PEEP) may induce lung overinflation and increased pulmonary vascular resistance to flow. In 8 healthy mechanically ventilated pigs, we evaluated whether incident dark field (IDF) vital microscopy, applied through a small thoracotomy, could be used to evaluate changes in alveolar and pulmonary microvessel dimensions under different ventilator settings. High TV (12 ml/kg) increased alveolar diameters (from 99 ± 13 to 114 ± 6 μm, p < 0.05 repeated measures one way analysis of variance) and reduced septal capillary diameters (from 12.1 ± 1.7 to 10.5 ± 1.4 μm, p < 0.001) as compared to 8 ml/kg TV. This effect was more pronounced in non-dependent lung. Alveolar and microvessel diameters did not change with high PEEP (12 cmH

Indexed as

MicrovesselsPulmonary AlveoliTidal VolumeAnimalsLungPositive-Pressure RespirationRespiration, ArtificialSwineHand-held vital microscopyIncident dark fieldMechanical ventilationPulmonary microcirculationVentilation/perfusion matching

Identifiers

PMID39639087
PMCPMC11621561

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.