Evidence map›Paper›PMID 39639036›Full record

SynthesisScientific reports2024

Critical genes in genitourinary embryogenesis are related to the development of adult hydrocele.

Jeffrey L Roberson, Christopher J Neylan, Renae Judy, Venexia Walker, Philip S Tsao, Scott M Damrauer, Lillias H Maguire

Abstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jeffrey L RobersonDepartment of Surgery, Perelman School of Medicine, Philadelphia, PA, USA.
Christopher J NeylanDepartment of Surgery, Perelman School of Medicine, Philadelphia, PA, USA.
Renae JudyDepartment of Surgery, Perelman School of Medicine, Philadelphia, PA, USA.
Venexia WalkerMedical Research Council Integrative Epidemiology Unit, University of Bristol, Bristol, UK.
Philip S TsaoVA Palo Alto Epidemiology Research and Information Center for Genomics, VA Palo Alto Health Care System, Palo Alto, CA, USA.
Scott M DamrauerDepartment of Surgery, Perelman School of Medicine, Philadelphia, PA, USA.
Lillias H MaguireCorporal Michael J. Crescenz Memorial Veterans Affairs Medical Center, Philadelphia, PA, USA. lillias.maguire@pennmedicine.upenn.edu.

Funding

NRSA Training CoreTL1TR001880 · NCATS · UNIVERSITY OF PENNSYLVANIA · PI MEAGHER, EMMA ANNE · 2016 to 2025
$10.0M
Genetic Determinants of Outcomes in Diverticular DiseaseK08DK124687 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI MAGUIRE, LILLIAS HOLMES · 2020 to 2024
$841k
NCATS NIH HHS TL1 TR001880NIDDK NIH HHS 1K08DK124687NIDDK NIH HHS K08 DK124687
6 · The paper itself

Abstract

Despite being a common urologic disorder with potentially complicated sequela, the genetic background of adult hydrocele has not previously been described. We performed a multi-population genome-wide association study of 363,460 men in the United Kingdom BioBank and FinnGen cohorts. We identified 6,548 adult men with hydrocele. We analyzed common variants (minor allele frequency > 0.01) associated with hydrocele and set the threshold for genome-wide significance at p < 5 × 10

Indexed as

Genome-Wide Association StudyTesticular HydroceleAdultAgedEmbryonic DevelopmentHumansMaleMiddle AgedPolymorphism, Single NucleotideUnited KingdomUrogenital SystemGWASHerniorrhaphyHydrocele

Identifiers

PMID39639036
PMCPMC11621517

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.