SynthesisClinical oral investigations2024
Correlation of Porphyromonas gingivalis with esophageal squamous cell carcinoma: a systematic review.
Synthesis in Clinical oral investigations, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Oral Health-Related Quality of Life and Oral Health Indices in Patients With Opioid Use Disorder Undergoing Methadone Maintenance Treatment.International journal of dentistry · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThis study aimed to assess the correlation of Porphyromonas gingivalis (P. gingivalis) with esophageal squamous cell carcinoma (ESCC). MATERIALS AND
methodsThis systematic review evaluated case-control, cohort, and cross-sectional studies published between 1990 and 2024 that compared ESCC patients and healthy controls regarding the presence of P. gingivalis, risk of ESCC development, overall survival rate and prognosis of ESCC, lymph node metastasis, clinical stage of the disease, cancer cell proliferation and migration, efficacy of chemotherapy, invasion depth, and cell differentiation. Searching process was conducted in Web of Science, Scopus, PubMed, and Cochrane Library. The quality of included studies was assessed by the Newcastle Ottawa scale (NOS).
resultsOf 270 articles, 11 underwent a systematic review with NOS scores ranging from 7 to 9. 5 studies found a correlation between P.gingivalis and overall survival rate of ESCC patients (P < 0.05). 5 studies found a significant correlation between P.gingivalis count and the risk of ESCC development (P < 0.05). 2 studies showed a significant correlation between lymph node metastasis and 3 studies showed a significant correlation between clinical TNM stage and P.gingivalis (P < 0.05).
conclusionsHigh P. gingivalis count increases the risk of development of ESCC, lymph node metastasis, progression to stages 3 and 4, proliferation and migration of cancer cells, and depth of invasion, decreases the overall survival rate and prognosis of the disease, and efficacy of chemotherapy, and results in poorer differentiation of cells. CLINICAL RELEVANCE: According to our findings, dental clinicians and patients should be informed about the significance of oral hygiene and its relationship with ESCC to prevent future life-threatening diseases.
Indexed as
Identifiers
39638908What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.