Evidence map›Paper›PMID 39638893›Full record

ArticleScientific reports2024

Relationship among ultrasound features, pus Mycobacterium tuberculosis load, and efficacy of antituberculosis drugs in patients with necrotizing tuberculous lymphadenitis.

Ying Zhang, Ting Lin, Hao Li, Peijun Chen, Yuehui Yu, Xinyi Yan, Yuanyuan Chen, Gaoyi Yang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ying Zhang *Department of Ultrasonography, Hangzhou Red Cross Hospital, Hangzhou, Zhejiang, China.
Ting Lin *The Fourth Clinical Medical College, Zhejiang Chinese Medicine University, Hangzhou, China.
Hao LiDepartment of Clinical Laboratory Center, Hangzhou Red Cross Hospital, Hangzhou, Zhejiang, China.
Peijun ChenDepartment of Ultrasonography, Hangzhou Red Cross Hospital, Hangzhou, Zhejiang, China.
Yuehui YuDivision of Health Sciences, Hangzhou Normal University, Hangzhou, Zhejiang, China.
Xinyi YanDivision of Health Sciences, Hangzhou Normal University, Hangzhou, Zhejiang, China.
Yuanyuan ChenDepartment of Clinical Medical Experimental Testing Center, Hangzhou Red Cross Hospital, Hangzhou, Zhejiang, China.
Gaoyi YangDepartment of Ultrasonography, Hangzhou First People's Hospital, Hangzhou, Zhejiang, China. yanggaoyi8@163.com.

Funding

the Medical Science and Technology Project of Zhejiang Province 2022KY986the Medical Science and Technology Project of Zhejiang Province 2023KY970the pre-research fund project of Zhejiang University ZAYY 10
6 · The paper itself

Abstract

For patients with necrotizing cervical tuberculous lymphadenitis (CTL) who have formed abscesses and are unwilling to undergo surgery, early and accurate assessment of drug therapy should be performed to guide subsequent clinical adjustments. This study investigated 22 patients with necrotizing CTL who underwent chemotherapy at our hospital from February 2020 to December 2022. They were diagnosed based on the positive results of pathogen detection methods (acid-fast bacillus smear, mycobacteria culture, Gene X-pert, and next-generation sequencing). Based on the 6-month treatment outcomes, the relationship among prechemotherapy ultrasound features, pus Mycobacterium tuberculosis (MTB) load, and treatment efficacy was assessed. In this study, the maximum lymph node (LN) area, maximum necrotic area, and pus MTB load in patients with necrotizing CTL were associated with poor prognosis and showed significant differences between the effective and ineffective groups (P < 0.05). However, no statistical difference was observed in the maximum longitudinal diameter, short diameter, and necrosis rate between the two groups (P > 0.05). The maximum necrotic area of the LNs was not associated with the pus MTB load. Furthermore, maximum LN area, maximum necrotic area, and pus bacterial load may be potential radiological markers for predicting the therapeutic response of CTL.

Indexed as

Antitubercular AgentsBacterial LoadMycobacterium tuberculosisTuberculosis, Lymph NodeUltrasonographyAdultFemaleHumansLymph NodesMaleMiddle AgedNecrosisTreatment OutcomeYoung AdultAntitubercular AgentsAntituberculosis therapyMTB loadNecrosisNecrotizing cervical tuberculous lymphadenitisTuberculous lymphadenitisUltrasound

Identifiers

PMID39638893
PMCPMC11621777

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.