Evidence map›Paper›PMID 39638876›Full record

ArticleNature biomedical engineering2025

A foundation model for enhancing magnetic resonance images and downstream segmentation, registration and diagnostic tasks.

Yue Sun, Limei Wang, Gang Li, Weili Lin, Li Wang

Abstract read
In one paragraph

Article in Nature biomedical engineering, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed.

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  17. Vision-language framework for multi-sequence brain magnetic resonance imaging.medRxiv : the preprint server for health sciences · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Yue SunDeveloping Brain Computing Lab, Department of Radiology and Biomedical Research Imaging Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.ORCID http://orcid.org/0000-0003-3151-6774
Limei WangDeveloping Brain Computing Lab, Department of Radiology and Biomedical Research Imaging Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Gang LiDepartment of Radiology and Biomedical Research Imaging Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.ORCID http://orcid.org/0000-0001-9585-1382
Weili LinDepartment of Radiology and Biomedical Research Imaging Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.ORCID http://orcid.org/0000-0002-2900-8204
Li WangDeveloping Brain Computing Lab, Department of Radiology and Biomedical Research Imaging Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. li_wang@med.unc.edu.ORCID http://orcid.org/0000-0003-2165-0080

Funding

UNC/UMN Baby Connectome ProjectU01MH110274 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI ELISON, JED THOMAS, GILMORE, JOHN HORACE · 2016 to 2019
$4.5M
Mapping Trajectories of Alzheimer's Progression via Personalized Brain Anchor-nodesR01AG075582 · NIA · UNIVERSITY OF TEXAS ARLINGTON · PI Gang Li, Dajiang Zhu · 2022 to 2026
$2.7M
Infant Brain and Behavioral Signatures of Later Emerging Risk for PsychopathologyR01MH104324 · NIMH · UNIVERSITY OF MINNESOTA · PI ELISON, JED THOMAS · 2014 to 2018
$2.6M
Continued Development of Infant Brain Analysis ToolsR01MH117943 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI LI, GANG, WANG, LI · 2018 to 2022
$2.3M
Parcellating Infant Cerebral Cortex based on Developmental Patterns of Multimodal MRIR01MH116225 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI LI, GANG · 2018 to 2022
$1.9M
Developing an Individualized Deep Connectome Framework for ADRD AnalysisRF1NS128534 · NINDS · UNIVERSITY OF TEXAS ARLINGTON · PI LI, GANG, LIU, TIANMING · 2022 to 2022
$1.7M
Computational Neuroimaging MRI for Studying Early Brain Development with AutismR01MH133845 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Li Wang · 2024 to 2026
$1.5M
Developing an Individualized Deep Connectome Framework for ADRD AnalysisR01NS128534 · NINDS · UNIVERSITY OF TEXAS ARLINGTON · PI Gang Li, Tianming Liu · 2025 to 2026
$878k
Harmonizing and Archiving of Large-scale Infant Neuroimaging DataRF1MH123202 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI LI, GANG · 2021 to 2021
$627k
NIA NIH HHS R01 AG075582NIMH NIH HHS R01 MH104324NIMH NIH HHS R01 MH116225NIMH NIH HHS R01 MH117943NIMH NIH HHS R01 MH133845NIMH NIH HHS RF1 MH123202NIMH NIH HHS U01 MH110274NINDS NIH HHS R01 NS128534NINDS NIH HHS RF1 NS128534U.S. Department of Health & Human Services | National Institutes of Health (NIH) AG075582U.S. Department of Health & Human Services | National Institutes of Health (NIH) MH116225U.S. Department of Health & Human Services | National Institutes of Health (NIH) NS128534U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) MH116225U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) MH117943U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) MH123202U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) MH133845U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) U01MH110274
6 · The paper itself

Abstract

In structural magnetic resonance (MR) imaging, motion artefacts, low resolution, imaging noise and variability in acquisition protocols frequently degrade image quality and confound downstream analyses. Here we report a foundation model for the motion correction, resolution enhancement, denoising and harmonization of MR images. Specifically, we trained a tissue-classification neural network to predict tissue labels, which are then leveraged by a 'tissue-aware' enhancement network to generate high-quality MR images. We validated the model's effectiveness on a large and diverse dataset comprising 2,448 deliberately corrupted images and 10,963 images spanning a wide age range (from foetuses to elderly individuals) acquired using a variety of clinical scanners across 19 public datasets. The model consistently outperformed state-of-the-art algorithms in improving the quality of MR images, handling pathological brains with multiple sclerosis or gliomas, generating 7-T-like images from 3 T scans and harmonizing images acquired from different scanners. The high-quality, high-resolution and harmonized images generated by the model can be used to enhance the performance of models for tissue segmentation, registration, diagnosis and other downstream tasks.

Indexed as

BrainImage Processing, Computer-AssistedMagnetic Resonance ImagingAdolescentAdultAgedAlgorithmsArtifactsChildFemaleGliomaHumansInfantMaleMiddle AgedMultiple Sclerosis

Identifiers

PMID39638876
PMCPMC12360180

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.