Evidence map›Paper›PMID 39638849›Full record

ArticleScientific reports2024

Microplastic particles in human blood and their association with coagulation markers.

Dong-Wook Lee, Jaehak Jung, Seul-Ah Park, Yunjeong Lee, Juyang Kim, Changwoo Han, Hwan-Cheol Kim, Joon Hee Lee, Yun-Chul Hong

Abstract read
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Health impacts of micro- and nanoplastics in humans: systematic review of in vivo evidence.Environmental health : a global access science source · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Dong-Wook LeeDepartment of Occupational and Environmental Medicine, Inha University Hospital, Inha University, Incheon, Republic of Korea. taesanglee89@inha.ac.kr.
Jaehak JungKorea Institute of Analytical Science and Technology, Seoul, Republic of Korea.
Seul-Ah ParkKorea Institute of Analytical Science and Technology, Seoul, Republic of Korea.
Yunjeong LeeKorea Institute of Analytical Science and Technology, Seoul, Republic of Korea.
Juyang KimKorea Institute of Analytical Science and Technology, Seoul, Republic of Korea.
Changwoo HanDepartment of Preventive Medicine, College of Medicine, Chungnam University, Daejeon, Republic of Korea.
Hwan-Cheol KimDepartment of Occupational and Environmental Medicine, Inha University Hospital, Inha University, Incheon, Republic of Korea.
Joon Hee LeeDepartment of Laboratory Medicine, Seoul National University Bundang Hospital, Seongnam, Republic of Korea.
Yun-Chul HongDepartment of Human Systems Medicine, College of Medicine, Seoul National University, Seoul, Republic of Korea.

Funding

Ministry of Education RS-2023-00248956
6 · The paper itself

Abstract

Recent studies have indicated potential health risks associated with microplastics (MPs) exposure, including alterations in blood coagulation homeostasis. This cross-sectional study aimed to quantitatively examine MPs in human blood and assess their association with coagulation markers. We recruited 36 healthy adults, collected whole blood samples, and analyzed MPs using Fourier-transform infrared (µ-FTIR) spectroscopy. Lifestyle factors related to MP exposure were assessed, such as the use of plastic food containers. Coagulation and inflammatory markers in blood samples were analyzed, including C-reactive protein, prothrombin time, activated partial prothrombin time (aPTT), antithrombin III, platelet count, erythrocyte sedimentation rate, and fibrinogen. MPs were detected in 88.9% of the participants, with a mean concentration of 4.2 MPs/mL. The predominant types of plastics identified were polystyrene and polypropylene. MPs were significantly higher in participants with a greater use of plastic food containers. A high MP load in the blood (≥ 3 MPs/mL) was significantly correlated with increased aPTT, C-reactive protein, and fibrinogen. We identified MPs in human blood, their association with specific lifestyle factors, and significant alterations in coagulation markers. This underscores the need for strategies to reduce human exposure to MPs, particularly in relation to blood coagulation and potential cardiovascular risks.

Indexed as

BiomarkersBlood CoagulationMicroplasticsAdultC-Reactive ProteinCross-Sectional StudiesFemaleFibrinogenHumansMaleMiddle AgedProthrombin TimeSpectroscopy, Fourier Transform InfraredBiomarkersC-Reactive ProteinFibrinogenMicroplasticsBlood coagulationFourier-transform infrared spectroscopyHuman whole bloodInflammation markersLifestyle factorsMicroplastics

Identifiers

PMID39638849
PMCPMC11621780

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.