ArticleNature communications2024
Synaptic connectome of the Drosophila circadian clock.
Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.
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Who cites it
54 citing papers in PubMed.
- Core circadian clock genes control molecular and behavioral circatidal rhythms in Parhyale hawaiensis.Current biology : CB · 2026Article
- Cell-type-specific circadian and light-responsive transcriptional dynamics in adultProceedings of the National Academy of Sciences of the United States of America · 2026Article
- Brain circadian clock neurons drive fitness advantages iniScience · 2026Article
- Circadian Rhythms Time Seizure Severity inJournal of biological rhythms · 2026Article
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- Fat body CLOCK restrains innate immunity and maintains survival under dietary stress inbioRxiv : the preprint server for biology · 2026Article
- Knockout analysis of period and timeless and EGFP-based visualization of per-expressing clock cells in the cricket circadian clock.Zoological letters · 2026Article
- The Synaptic Clock: SynGAP1 as a Molecular Timer of Postsynaptic Density Consolidation.Biomolecules · 2026Review
- Circadian control of a sex-specific behavior ineLife · 2026Article
- A day sleep promoting role of phototransduction inNeurobiology of sleep and circadian rhythms · 2026Article
- The evolution of lepidopteran brain morphology.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2026Article
- THERM-D Uncovers Distinct Neural Mechanisms Separating Morning and Evening Body Temperature Rhythms inbioRxiv : the preprint server for biology · 2026Article
- Soma CaCurrent biology : CB · 2026Article
- Octopamine signaling from clock neurons plays dual roles in Drosophila long-term memory.PLoS genetics · 2026Article
- Hsp90 buffers behavioral variability by regulating Pdf transcription in clock neurons of Drosophila melanogaster.PLoS genetics · 2026Article
- Behavioral adaptation to warm conditions via Lim1-mediated acceleration of neuronal clocks.Nature neuroscience · 2026Article
- Review
- Shaker potassium channel mediates an age-sensitive neurocardiac axis regulating sleep and cardiac function in Drosophila.Biogerontology · 2026Article
- Clock-related neuropeptides inFrontiers in genetics · 2026Article
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Authors and funding
11 authors.
Funding
Abstract
The circadian clock and its output pathways play a pivotal role in optimizing daily processes. To obtain insights into how diverse rhythmic physiology and behaviors are orchestrated, we have generated a comprehensive connectivity map of an animal circadian clock using the Drosophila FlyWire brain connectome. Intriguingly, we identified additional dorsal clock neurons, thus showing that the Drosophila circadian network contains ~240 instead of 150 neurons. We revealed extensive contralateral synaptic connectivity within the network and discovered novel indirect light input pathways to the clock neurons. We also elucidated pathways via which the clock modulates descending neurons that are known to regulate feeding and reproductive behaviors. Interestingly, we observed sparse monosynaptic connectivity between clock neurons and downstream higher-order brain centers and neurosecretory cells known to regulate behavior and physiology. Therefore, we integrated single-cell transcriptomics and receptor mapping to decipher putative paracrine peptidergic signaling by clock neurons. Our analyses identified additional novel neuropeptides expressed in clock neurons and suggest that peptidergic signaling significantly enriches interconnectivity within the clock network.
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